Children's toxicology from bench to bed - Drug-induced Renal Injury (1) : The toxic effects of ARB/ACEI on fetal kidney development
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概要
- 論文の詳細を見る
Development of fetal kidney is a finely programmed sequence, and is regulated by many important molecules. The perturbation of normal kidney development leads to congenital anomalies of kidney and urinary tract (CAKUT). CAKUT includes hypoplastic/dysplastic kidney, obstructive nephropathy and several other anomalies. CAKUT is of clinically importance, since it could lead to end stage renal failure when its anomaly grade is severe. So far, several causative genes responsible for development of CAKUT have been identified, including genes encoding molecules related to the renin-angiotensin-aldosterone system, RAS system. In humans, maternal administration of agents with inhibitory effects on the RAS system, such as angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin type 1 receptor blockers (ARBs), have been reported to cause severe renal malformation, designated as ACEI/ARB fetopathy. In this paper, we overview the development of fetal kidney and address the effects of ACEIs/ARBs on fetal kidney.
- 日本トキシコロジー学会の論文
著者
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TAKAHASHI Kazuhiro
Department of Medicine, Hamanomachi Hospital
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Sekine Takashi
Department Of Pediatrics Gradate School Of Medicine The University Of Tokyo
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IGARASHI Takashi
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
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Igarashi Takashi
Department Of Drug Metabolism And Pharmacokinetics Kawanishi Pharma Research Institute Nippon Boehri
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Igarashi Takashi
Department Of Pediatrics Graduate School Of Medicine The University Of Tokyo
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Sekine Takashi
Department Of Pediatrics Graduate School Of Medicine The University Of Tokyo
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Miura Ken-ichiro
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
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Miura Ken-ichiro
Department Of Pediatrics Graduate School Of Medicine The University Of Tokyo
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Sekine Takashi
Department Of Applied Chemistry Tokyo Metropolitan University
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Igarashi Takashi
Department Of Anesthesia Mitsui Memorial Hospital
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Takahashi Kazuhiro
Department Of Dermatology Iwate Medical University School Of Medicine
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Takahashi Kazuhiro
Department Of Pediatrics Graduate School Of Medicine The University Of Tokyo
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Takahashi Kazuhiro
Department Of Cardiology Japanese Red Cross Nagasaki Genbaku Hospital
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TAKAHASHI Kazuhiro
Department of Analytical Medical Technology, Tohoku University School of Health Sciences
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