Plasma glutathione S-transferase in carbon tetrachrolide treated rats and its association to hepatic cytosolic isozymes.
スポンサーリンク
概要
- 論文の詳細を見る
The effect of carbon tetrachloride (CCl<SUB>4</SUB>) treatment on plasma and liver cytosolic glutathione S-transferase (GST) activities was investigated in rats. CCl<SUB>4</SUB> was intraperitoneally administered at a dose of 0.5 ml/kg. The elevation of plasma GST activity paralleled the increase of plasma glutamate pyruvate transaminase activity after the administration of CCl<SUB>4</SUB>. Liver cytosolic GST activities were significantly decreased by CCl<SUB>4</SUB> treatment. To establish the relationship of plasma GST with liver cytosolic isozymes, Western blot analysis using antibodies against cytosolic GST 1-2 and 3-4 was performed. The Western blots showed the existence of GST 1-2 and 3-4 in plasma at 24 hr after CCl<SUB>4</SUB> treatment. The data thus strongly suggest that cytosolic GSTs are lost from the liver to plasma as a consequence of liver damage. The Western blot analysis of plasma GST may be useful for monitoring liver damage.
- 公益社団法人 日本薬理学会の論文
著者
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Ohmori Shigeru
Department Of Pharmacy Shinshu University Hospital
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Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
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Igarashi Takashi
Department Of Anesthesia Mitsui Memorial Hospital
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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MURAMATSU Hideko
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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OHMORI Shigeru
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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IGARASHI Takashi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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