Children's toxicology from bench to bed - Drug-induced Renal Injury (2) : Nephrotoxiciy induced by cisplatin and ifosfamide in children
スポンサーリンク
概要
- 論文の詳細を見る
Cisplatin and carboplatin cause dose-dependent renal dysfunction. Electrolyte abnormalities such as hypomagnesaemia and hypokalemia are commonly reported adverse effects, in addition to increased serum creatinine and uremia. Cumulative dose, dehydration, hypoalbuminemia, and concurrent use of nephrotoxic drugs have been suggested as risk factors for cisplatin nephrotoxicity. The adverse effects of ifosfamide include proximal tubular damage, and renal wasting of electrolytes, glucose and amino acids, Fanconi syndrome, rickets and osteomalacia have also been reported with ifosfamide treatment. Risk factors for ifosfamide nephrotoxicity include the cumulative dose, young age, previous or concurrent cisplatin treatment, and unilateral nephrectomy. Ifosfamide/Carboplatin/Etoposide (ICE) combination therapy induces hypouricemia, which frequently includes renal wasting of electrolytes, and persistent hypouricemia has been observed in recurrent or chemotherapy-resistant patients. We retrospectively examined the incidence of hypouricemia and clinical findings in pediatric patients treated with an ICE regimen. Twenty of 28 (71.4%) pediatric patients had hypouricemia. The duration of hypouricemia was longer in the non-remission subgroup of patients, which suggests that hypouricemia may be a predictive marker for prognosis of malignant disease and efficacy of drugs such as ifosfamide, carboplatin and cisplatin. Nephrotoxicity induced by these drugs may also be more common in pediatric patients than in adults, but it is unclear why a young age is a risk factor and further research is required regarding the mechanism of antineoplastic drug induced-nephrotoxicity in children.
著者
-
FUJIEDA Mikiya
Department of Pediatrics, Kochi Medical School, Kochi University
-
Sekine Takashi
Department Of Pediatrics Gradate School Of Medicine The University Of Tokyo
-
Matsunaga Akira
Department Of Anesthesiology And Critical Care Medicine Kagoshima University Graduate School Of Medi
-
Fujieda Mikiya
Department Of Pediatrics Kochi Medical School Kochi University
-
Chayama Kohsuke
Department Of Pediatrics Okayama University Graduate School Of Medicine And Dentistry
-
Chayama Kohsuke
Department Of Padiatrics Osaka Medical Center And Research Institute For Maternal And Child Health
-
HAYASHI ATSUSHI
Division of Pediatrics & Perinatology, Faculty of Medicine, Tottori University
-
Fujieda Mikiya
Department Of Pediatric Nephrology Kidney Center Tokyo Women's Medical College
-
Tauchi Hiromichi
Department of Pediatrics, Ehime University School of Medicine
-
Tauchi Hiromichi
Department Of Pediatrics Ehime University School Of Medicine
-
Sekine Takashi
Department Of Pediatrics Graduate School Of Medicine And Faculty Of Medicine The University Of Tokyo
-
Sekine Takashi
Department Of Applied Chemistry Tokyo Metropolitan University
-
Hayashi Atsushi
Division Of Pediatrics And Perinatology Faculty Of Medicine Tottori University
-
Matsunaga Akira
Department Of Pediatrics School Of Medicine Yamagata University
関連論文
- Lethal Effect of Autolysate of a Jellyfish Aurelia aurita on Red-Tide Flagellates
- Children's toxicology from bench to bed - Drug-induced Renal Injury (3) : Drug transporters and toxic nephropathy in childhood
- サイトメガロウイルス感染症と乳児喘鳴
- Can a NICO monitor substitute for thermodilution to measure cardiac output in patients with coexisting tricuspid regurgitation?
- A short-acting beta-blocker, landiolol, attenuates systolic anterior motion of the mitral valve after mitral valve annuloplasty
- Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome
- PE-400 HDL-Raising Efficacy and the Effects of ROSuvastatin on Small, Dense Electronegative LDL as Characterized by CapillARY Isotachophoresis : The ROSARY Study(PE067,Lipid Disorders 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of th
- PJ-721 Comparison of LDL Subclasses as Analyzed by Quantitative Ultracentrifugation, Nuclear Magnetic Resonance Spectroscopy and Capillary Isotachophoresis(Lipid disorders(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- PE-354 Effect of Pitavastatin on Apolipoprotein A5 Secretion in HepG2 Cells(Lipid disorders(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-242 Pitavastatin Upregulates the Expression of the Apolipoprotein A5 in HepG2 Cell(Lipid disorders-3 (H) PJ41,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Human Chymase Expression in a Mice Induces Mild Hypertension with Left Ventricular Hypertrophy
- Antihypertensive and antihypertrophic effects of chymase inhibitor in human chymase transgenic mice
- Chymase-dependent angiotensin II formation causes mild hypertension and cardiac hypertrophy
- Mesangial myofibroblastic transformation in steroid-dependent minimal change nephrotic syndrome
- 小児腎移植患者における Epstain-Barr ウイルス(EBV)負荷量と抗体価のモニタリング
- Children's toxicology from bench to bed - Drug-induced Renal Injury (2) : Nephrotoxiciy induced by cisplatin and ifosfamide in children
- Strong Linkage Disequilibrium and Association of -1131T>C and c.553G>T Polymorphisms of the Apolipoprotein A5 Gene With Hypertriglyceridemia in a Japanese Population
- PJ-516 Apolipoprotein A5 Gene Polymorphisms, -1131T>C and c.553G>T were in Strong Linkage Disequilibria and Associated with Hypertriglyceridemia in Japanese(Lipid disorders-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical Significance of the Coronary Calcification Score by Multidetector Row Computed Tomography for the Evaluation of Coronary Stenosis in Japanese Patients
- Left Ventricular Pseudoaneurysm Following Acute Myocardial Infarction
- Potent Capillary Isotachophoresis (cITP) for Analyzing a Marker of Coronary Heart Disease Risk and Electronegative Low-Density Lipoprotein (LDL) in Small Dense LDL Fraction
- Histochemical Characteristics of Soleus Muscle in Angiotensin-Converting Enzyme Gene Knockout Mice
- Apolipoprotein A-V Gene Polymorphisms, G185C and-1131T>C Associated with Hypertriglyceridemia in Western Japanese Population(Lipid Disorders 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Detection and Quantification of Potentially Atherogenic Triglyceride-Rich Remnant Lipoprotein Subfraction Using Capillary Isotachophoresis(Lipid Disorders 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relation between Remnant-like Particle Fraction and Electronegative Low-Density Lipoprotein Subfraction in Patients with Hypercholesterolemia(Atherosclerosis, Clinical 14 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Characteristics of Brugada Syndrome with Atrial Fibrillation(Arrhythmia, Diagnosis/Pathophysiology/EPS 9 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A Comparative Crossover Study of the Effects of Fluvastatin and Pravastatin (FP-COS) on Circulating Autoantibodies to Oxidized LDL in Patients with Hypercholesterolemia
- Video-Assisted Thoracic Surgery Lobectomy for Extralobar Pulmonary Sequestration in a Child : Report of a Case
- P-21 Trasport of methyl mercury-cysteine conjugate by multispecific organic anion transport 3(Proceedings of the 27th Annual Meeting)
- Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis
- Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy
- Identification of Two Apolipoprotein Variants, A-I Kaho (Asp 51→Val) and A-I Lys 107 Deletion
- CHARACTERIZATION OF HUMAN APOLIPOPROTEIN A-I VARIANTS
- Infliximab Treatment for Refractory Kawasaki Disease With Coronary Artery Aneurysm : A 1-Month-Old Girl
- Human Organic Anion Transporters Mediate the Transport of Tetracycline
- Mild immunoglobulin A nephropathy in a patient with a marked increase in serum immunoglobulin A
- Purinoceptor-Mediated Calcium Mobilization and Cellular Proliferation in Cultured Bovine Corneal Endothelial Cells
- Molecular biology of multispecific organic anion transporter family (OAT family)
- 22D-09-3 Silica increases cytosolic calcium and causes cell injury in renal cell lines.
- evidence-based practice guideline for the treatment of chronic kidney disease
- Cibenzoline attenuates systolic anterior motion of the mitral valve after mitral valvoplasty
- CD34^+ progenitor cell transplantation from two HLA-mismatched healthy fathers to two infants with severe aplastic anemia
- Improvement of nephrotic syndrome by intensive lipid-lowering therapy in a patient with lipoprotein glomerulopathy
- Atrioventricular block in a patient with growth hormone deficiency during growth hormone therapy
- Acute renal failure after exercise in a child with renal hypouricemia
- Transport of ochratoxin A by renal multispecific organic anion transporter 1 and its effect on cell proliferation
- Bacteriophage therapy : a revitalized therapy against bacterial infectious diseases
- Children's toxicology from bench to bed - Drug-induced Renal Injury (1) : The toxic effects of ARB/ACEI on fetal kidney development
- Continuous, noninvasive measurement of cytochrome oxidase in cerebral cortex by near-infrared spectrophotometry during aortic arch surgery
- Enhancement of gene expression by a peptide p(CHWPR) produced by Bifidobacterium lactis BB-12
- Three patients with different phenotypes in a family with chromosome 22q11.2 deletions
- Aplastic Anemia during Growth Hormone (GH) Treatment in a Girl with ldiopathic GH-Deficiency
- Genetic Analysis of Brugada Syndrome in Western Japan : Two Novel Mutations
- pH-Dependent Dissociation of Carbohydrate Ligand Polycations from DNA Ternary Complexes
- Mizoribine oral pulse therapy for a patient with polyarticular juvenile idiopathic arthritis
- Immunohistochemical characterization of glomerular inflammatory cells and expression of adhesion molecules in antiglomerular basement membrane (anti-GBM) glomerulonephritis induced in WKY rats with monoclonal anti-GBM antibodies of different subclasses
- Efficacy of Additional Amiodarone Therapy in Patients with an Implantable Cardioverter-Defibrillator
- A Novel Mutation of Human Apolipoprotein A-V Gene, ApoA-V (Gly162Cys) : Influence of the Mutation on High Plasma Triglyceride Levels
- Fenofibrate and Pitavastatin Increase Transcriptional Levels of Apolipoprotein A-I Gene Variants at 5' Untranlation Region
- Structual and Functional Properties of Apolipoprotein A-I Mutants
- 乳幼児における Epstein-Barr ウイルスによる伝染性単核症の診断
- Statins Induce the Gene Expression of Apolipoprotein A5 in HepG2 Cells
- A case of pseudohomozygous type II hyperlipoproteinemia in early infancy
- Morphological and functional analyses of two infants with obstructive renal dysplasia
- Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation
- Methicillin-resistant Staphylococcus aureus bloodstream infections in a Japanese University Hospital between 1987 and 2004
- Reactivity of Direct Assays for Low-Density Lipoprotein (LDL) Cholesterol Toward Charge-Modified LDL in Hypercholesterolemia
- First reported case of hemoglobin lansing in Asia detected by false low oxygen saturation on pulse oximetry
- Phenotypic variability in a family with Townes-Brocks syndrome
- Molecular Analysis of TSC2/PKD1 Contiguous Gene Deletion Syndrome
- Xanthogranulomatous Cholecystitis Mimicking Gallbladder Cancer; Report of a Case.:Report of a Case
- The Structure and Synthesis of Rishitinol. A Sesquiterpene Alcohol from Diseased Potato Tubers
- Appendicitis Caused by Caecal Carcinoma: Report of a Case.
- Rishitin. I. The isolation and structure elucidation.
- Lubimin and oxylubimin. The structure elucidation.
- Renal disease in the elderly and the very elderly Japanese : analysis of the Japan Renal Biopsy Registry (J-RBR)
- A founder haplotype of APOE-Sendai mutation associated with lipoprotein glomerulopathy
- A novel approach to the histological diagnosis of pediatric nephrotic syndrome by low vacuum scanning electron microscopy
- Darbepoetin alfa for the treatment of anemia in children undergoing peritoneal dialysis: a multicenter prospective study in Japan
- Compound Heterozygotes for a Novel Mutation, Apo E1 Nagoya (Arg142Ser) and Apo E2 (Arg158Cys), with Severe Type III Hyperlipoproteinemia and Familial Hypercholesterolemia