Reactivity of Direct Assays for Low-Density Lipoprotein (LDL) Cholesterol Toward Charge-Modified LDL in Hypercholesterolemia
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概要
- 論文の詳細を見る
Background: The aim of the present study was to compare 2 direct measurements for low-density lipoprotein cholesterol (LDL-C) with the Friedewald calculation (LDL-C [F]) in serum and their relationship with size-and charge-based LDL subfractions in serum ultracentrifugation fractions in patients with hypercholesterolemia (HC). Methods and Results: Serum samples from 283 HC patients who participated in a statin trial (the PATROL trial) were analyzed. Homogeneous assays for LDL-C were performed using reagents from Sekisui Medical (LDL-C [Se]) and Kyowa Medex (LDL-C [Ky]). Charge-based LDL subfractions were analyzed by capillary isotachophoresis (cITP). In whole serum in HC patients at baseline, LDL-C (Se) and LDL-C (Ky) negatively and positively deviated, respectively, from LDL-C (F). The negative deviation of LDL-C (Se) from LDL-C (F) increased with increasing LDL-C, while the positive deviation of LDL-C (Ky) from LDL-C (F) was positively correlated with charge-modified LDL (cmLDL) as analyzed by cITP. In serum d>1.006g/ml and >1.040g/ml fractions (LDL and small, dense LDL fractions, respectively), the deviation of LDL-C (Ky) from LDL-C (Se) was positively correlated with LDL-apoB (the number of LDL particles) and cmLDL. Conclusions: The 2 homogenous assays for LDL-C differed with regard to reactivity toward LDL particles and cmLDL in patients with HC. Direct measurement of LDL-C that reflects modified LDL, could be a better marker for the risk of coronary heart disease. (Circ J 2012; 76: 2241–2248)
- 2012-08-25
著者
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Zhang Bo
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Suyama Kazuhiro
福岡大学 2内
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Imaizumi Satoshi
Department of Cardiology, Fukuoka University School of Medicine
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Kuroki Syoji
福岡大学 医学部循環器科
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Saku Keijiro
Department Of Cardiology Fukuoka University Faculty Of Medicine
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Saku Keijiro
福岡大学 医学研究科臨床研究科学
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Miura Shin-ichiro
Department Of Cardiology Fukuoka University Faculty Of Medicine
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Miura Shin-ichiro
福岡大学 医学部心臓血管内科学
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Matsunaga Akira
Department Of Cardiology Fukuoka University
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Matsunaga Akira
Department Of Anesthesiology And Critical Care Medicine Kagoshima University Graduate School Of Medi
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Noda Keita
Department Of Cardiology Fukuoka University
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Saku Keijiro
Department Of Cardiology Fukuoka University Hospital School Of Medicine
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UEHARA Yoshinari
Department of Cardiology, Fukuoka University School of Medicine
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Imaizumi Satoshi
Department Of Cardiology Fukuoka University School Of Medicine
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Kuroki Masahide
Department Of Biochemistry Cancer Research Institute
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Miura Shin-ichiro
Department Of Cardiology Fukuoka University School Of Medicine Fukuoka University
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Uehara Yoshinari
Department Of Cardiology Fukuoka University Faculty Of Medicine
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Saku Keijiro
Department Of Cardiology Fukuoka University School Of Medicine Fukuoka University
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Saku Keijiro
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Miura Shin-ichiro
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Zang Bo
Department Of Cardiology Fukuoka University School Of Medicine
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Muraoka Soichi
Department Of Cardiology Fukuoka University Hospital School Of Medicine
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Zhang Bo
Department Of Biochemistry Fukuoka University School Of Medicine
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Saku Keijiro
Department Of Internal Medicine School Of Medicine Fukuoka Universityr
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Kawachi Emi
Department Of Cardiology Fukuoka University Faculty Of Medicine
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YOSHINAGA Kazuhiko
Department of Research Laboratory for Social Medicine, Fukuoka University School of Medicine
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Yoshinaga Kazuhiko
Department Of Research Laboratory For Social Medicine Fukuoka University School Of Medicine
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