Studies on the Latex Agglutination Inhibition Method for Assay of Plasma Theophylline Concentration

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概要

• 論文の詳細を見る

• We studied the latex agglutination inhibition method (the Biotrack system) for rapid measurement of plasma theophylline concentrations. Blood was collected from patients hospitalized for treatment of bronchial asthma and from healthy volunteers. The plasma theophylline concentrations of the samples were also measured by two other systems : fluorescence polarization immunoassay and high performance liquid chromatography (HPLC). When the results were compared, it was found that some combinations of Biotrack 516 units and cartridges afforded high plasma theophylline concentrations for some patients. Using HPLC, we found that the high values were not due to cross-reactivity with theophylline or caffeine metabolites. After careful investigation, the high values appeared to result from the characteristics of the individual Biotrack 516 units and cartridges used. Re-evaluation after improved materials were introduced into the system of Biotrack manufacturing yielded theophylline concentrations that correlated significantly with those obtained by HPLC.

• 日本医療薬学会の論文
• 1996-08-10

著者

• HAYAKAWA Hiroshi

  Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University

• ONO HIDEKI

  Department of Pharmacy, Branch Hospital, the University of Tokyo

• Igarashi Takashi

  Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un

• Igarashi Takashi

  Department Of Drug Metabolism And Pharmacokinetics Kawanishi Pharma Research Institute Nippon Boehri

• Kizu Junko

  Department Of Pharmacy Branch Hospital Faculty Of Medicine University Of Tokyo

• Igarashi Takashi

  Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo

• Watanabe Kaoru

  Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo

• Imai Kazuhiro

  Department Of Aeronautics And Astronautics School Of Engineering University Of Tokyo:(present Addres

• Watanabe Kunitomo

  Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo

• Inatomi Jun

  Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo

• Iwata Tsutomu

  Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo

• Iwata Tsutomu

  Departmennt Of Pediatrics Mejirodai Campus University Of Tokyo

• WATANABE Shigekazu

  Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo

• Watanabe Shigekazu

  Department Of Pharmacy Branch Hospital Faculty Of Medicine University Of Tokyo

• Sasaki Kyoko

  Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo

• Ono Hideki

  Department Of Cardiology Ninon University Surugadai Hospital

• Imai Kazuhiro

  Department Of Analytical Pharmacochemistry Faculty Of Pharmaceutical Science University Of Tokyo

• Hayakawa Hiroshi

  Department Of Internal Medicine Graduate School Of Medicine The University Of Tokyo

• Hayakawa Hiroshi

  Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo

• Igarashi Takashi

  Department Of Anesthesia Mitsui Memorial Hospital

• Ono Hideki

  Department Of Pharmacy Branch Hospital Faculty Of Medicine University Of Tokyo

• Hayakawa Hiroshi

  Departmennt Of Pediatrics Mejirodai Campus University Of Tokyo

• Igarashi Takashi

  千葉大学 薬

• Igarashi Takashi

  Analytical And Metabolic Research Laboratories And Biological Research Laboratories Sankyo Co. Ltd.:faculty Of Pharmaceutical Sciences Chiba University

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