Effect of Regional Tracer Delay on CBF in Healthy Subjects Measured with Dynamic Susceptibility Contrast-Enhanced MRI : Comparison with ^<15>O-PET
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概要
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Purpose: Deconvolution based on truncated singular value decomposition (SVD deconvolution) is a promising method for measuring cerebral blood flow (CBF) with dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI), but it has proved extremely sensitive to tracer delay. The purpose of this study was to investigate the effect of regional tracer delay on CBF determined by SVD deconvolution (SVD-CBF). SVD-CBFs with and without correction for the delay were compared with CBF measured by positron emission tomography (PET-CBF), which is regarded as the gold standard for quantification of CBF. Methods: Perfusion MRI and PET were performed on seven healthy men. In the PET study, the CBF image was obtained with bolus injection of H215O and continuous arterial sampling. In the DSC-MRI study with bolus injection of Gd-based contrast agent, dynamic perfusion data were obtained with a 1.5T scanner at 1-s intervals by means of gradient-echo echo-planar imaging. CBF was determined by the SVD deconvolution method with and without correction for the tracer delay. Region-of-interest measurements were obtained in the gray matter (cerebral cortex in the middle cerebral artery territory) and white matter (centrum semiovale). Results: Tracer delay was significantly longer in white matter than in gray matter (1.45±0.61 s vs. 0.59±0.35 s, P<0.01). Correction for the delay increased SVD-CBF in the white matter and consequently reduced the gray-to-white SVD-CBF ratio. The uncorrected gray-to-white SVD-CBF ratio was significantly larger than that of PET-CBF (3.33±0.66 vs. 2.54±0.49, P<0.01). However, the gray-to-white delay-corrected SVD-CBF ratio did not differ significantly from that of PET-CBF (2.83±0.31 vs. 2.54±0.49, P=0.10). Conclusion: The tracer delay in DSC-MRI causes errors in CBF estimates, even in healthy persons, and therefore should be corrected for when delay-sensitive deconvolution, such as SVD deconvolution, is used.
- 日本磁気共鳴医学会の論文
- 2005-06-01
著者
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ITO Hiroshi
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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IBARAKI Masanobu
Department of Quantum Science and Energy Engineering, Tohoku University
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伊藤 春海
福井大学医学部放射線科
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Ito H
National Inst. Radiological Sci. Chiba Jpn
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TAKAHASHI Kazuhiro
Department of Medicine, Hamanomachi Hospital
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Kanno Iwao
秋田県立脳血管研究センター
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Kanno I
Department Of Radiology And Nuclear Medicine Akita Research Institute Of Brain And Blood Vessels
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KANNO Iwao
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
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SHIMOSEGAWA Eku
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
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MIURA Shuichi
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
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Kanno Iwao
Akita Research Institute Of Brain And Blood Vessels
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Iida H
Department Of Investigative Radiology Research Institute National Cardio Vascular Center
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Miura S
Department Of Radiology And Nuclear Medicine Akita Research Institute Of Brain And Blood Vessels
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Itoh H
Department Of Radiology Faculty Of Medicine University Of Fukui
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Ito Hiroshi
National Inst. Radiological Sci. Chiba Jpn
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Kanno Iwao
Department Of Radiology And Nuclear Medicine Akita Research Institute For Brain And Vessels
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Iida Hidehiro
Department Of Investigative Radiology Research Institute National Cardio Vascular Center
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伊藤 春海
福井大学医学部
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TOYOSHIMA Hideto
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
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ISHIGAME Keiichi
PET Center, Kofu Neurosurgical Hospital
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Ibaraki Masanobu
Department Of Quantum Science And Energy Engineering Tohoku University
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Ito Hiroshi
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Miura Shuichi
Department Of Radiology And Nuclear Medicine Akita Research Institute Of Brain And Blood Vessels
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Ishigame Keiichi
Pet Center Kofu Neurosurgical Hospital
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Shimosegawa Eku
Department Of Nuclear Medicine And Tracer Kinetics Osaka University Graduate School Of Medicine
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Shimosegawa Eku
Akita Res. Inst. Brain And Blood Vessels Akita Jpn
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Kanno Iwao
Department Of Biophysics Molecular Imaging Center National Institute Of Radiological Sciences
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Toyoshima Hideto
Department Of Radiology And Nuclear Medicine Akita Research Institute Of Brain And Blood Vessels
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Miura Shuichi
Akita Res. Inst. Brain And Blood Vessels Akita Jpn
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Ito Hiroshi
Department Neurosurgery Tokyo Medical College
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Takahashi Kazuhiro
Department Of Dermatology Iwate Medical University School Of Medicine
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Takahashi Kazuhiro
Department Of Radiology And Nuclear Medicine Akita Research Institute Of Brain And Blood Vessels
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Takahashi Kazuhiro
Department Of Cardiology Japanese Red Cross Nagasaki Genbaku Hospital
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TAKAHASHI Kazuhiro
Department of Analytical Medical Technology, Tohoku University School of Health Sciences
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SHIMOSEGAWA Eku
Department of Radiology and Nuclear Medicine, Akita Research Institute, of Brain and Blood Vessels
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