Changes in Brain Glutamine Synthetase Activity in Congenital Hydrocephalic Rats [LEW-HYR] after Ventriculoperitoneal Shunt
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概要
- 論文の詳細を見る
先天性水頭症のグリア細胞機能障害を確かめる為に、先天性水頭症ラット (LEW-HYR) に対するVentriculoperitoneal (VP) shuntが、グルタミン合成酵素 (GS) 活性に与える影饗について検討した。その結果はVP shunt施行後、Methionine sulfoximin (MSO) に対する反応は正常群のレベルまで回復したが、hydrocortisoneに対しては正常群にみられる様なGS活性の増強は認められなかった。これらのことより、LEW-HYRのGS活性に対するVP shuntの効果は完全ではなく、特にhydrocortisoneの様にm-RNAを介する反応には全く影響を及ぼさず、グリア細胞はgeneticallyに障害されている可能性が示唆された。
- 日本脳神経外科学会の論文
- 1997-09-15
著者
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ITO Hiroshi
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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山田 裕二
愛知医科大学 脳神経外科
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山田 裕二
東京医科大学脳神経外科
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WATANABE Yasuo
Pharmacology, Tokyo Medicai College
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Ito Hiroshi
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Watanabe Yasuo
Pharmacology Tokyo Medicai College
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Ito Hiroshi
Department Neurosurgery Tokyo Medical College
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山田 裕二
東京医科大学病院脳神経外科
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