Effect of Having a Sense of Purpose in Life on the Risk of Death from Cardiovascular Diseases
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概要
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Background: Many studies have focused on disease causality, but few of them deal with health-promoting factors. Thus, we examined the effect of having a sense of purpose in life (ikigai) on mortality from cardiovascular disease (CVD). Methods: In 1988, we conducted a prospective cohort study of 2,959 Japanese subjects, ranging in age from 40 to 74 years, and followed them till the end of 2003. The level of their sense of purpose in life was evaluated by a self-administered questionnaire. After excluding those with a history of heart disease, stroke, or malignant tumor, 1,618 subjects (832 men and 786 women) who had completed the questionnaire were used in the analyses with Coxs proportional hazards model. Results: During the average 13.3 years of follow up, 249 deaths (172 men and 77 women) occurred as a result of all causes: 32 from heart disease, 31 from stroke, 63 from CVD, and 104 from malignant tumors. The adjusted hazard ratios for death in men with a strong sense of purpose in life, as compared with those with a low sense of purpose, were 0.28 (95% confidence interval: 0.10-0.84) for stroke, 0.56 (0.28-1.10) for CVD, and 0.62 (0.45-0.86) as a result of all causes. In women, no significant relationship was found between having a sense of purpose in life and mortality; this was possibly because the smaller number of deaths reduced the statistical significance. Conclusion: We found that in men, having a sense of purpose in life affected the risk of death as a result of all causes, stroke, and CVD.
- 日本疫学会の論文
- 2008-09-01
著者
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KOIZUMI Megumi
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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KANEKO Yoshihiro
Department of Public Health, Akita University Faculty of Medicine
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MOTOHASHI Yutaka
Department of Public Health, Akita University Faculty of Medicine
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ITO Hiroshi
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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Kaneko Yoshihiro
Department Of Internal Medicine Jikei University School Of Medicine
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Koizumi Megumi
Department Of Internal Medicine Division Of Cardiovascular Medicine Akita University Faculty Of Medi
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Koizumi Megumi
Department Of Bacteriology The Kitasato Institute
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Motohashi Yutaka
Department Of Public Health Akita University Faculty Of Medicine
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Ito Hiroshi
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Kaneko Yoshihiro
Department Of Public Health Akita University Faculty Of Medicine
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Kaneko Yoshihiro
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
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Motohashi Yutaka
Department Of Hygiene Faculty Of Medicine Tokyo Medical And Dental University
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Ito Hiroshi
Department Neurosurgery Tokyo Medical College
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