In Situ Hybridization Method Reveals (Pro)renin Receptor Expressing Cells in the Pituitary Gland of Rats: Correlation with Anterior Pituitary Hormones
スポンサーリンク
概要
- 論文の詳細を見る
Expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, was studied in rat pituitary gland. In situ hybridization showed that cells expressing (P)RR mRNA were widely distributed in the anterior lobe and intermediate lobe of the pituitary gland. Double-staining using in situ hybridization for (P)RR mRNA and immunohistochemistry for the pituitary hormones showed that (P)RR mRNA was expressed in most of the GH cells and ACTH cells in the anterior lobe. (P)RR mRNA was also expressed in a few prolactin cells and TSH cells, but not in LH cells. The present study has shown for the first time the distribution of (P)RR mRNA expressing cells in the rat pituitary gland. These findings suggest that (P)RR plays physiological roles in the pituitary gland, such as the modulation of the pituitary hormone secretion.
著者
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Hirose Takuo
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Totsune Kazuhito
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Fujiwara Ken
Division Of Histology And Cell Biology Department Of Anatomy Jichi Medical University School Of Medi
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Yatabe Megumi
Division Of Histology And Cell Biology Department Of Anatomy Jichi Medical University School Of Medi
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Yashiro Takashi
Division Of Histology And Cell Biology Department Of Anatomy Jichi Medical School
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TAKAHASHI Kazuhiro
Department of Analytical Medical Technology, Tohoku University School of Health Sciences
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Totsune Kazuhito
Department of Social Welfare, Faculty of Synthetic Welfare, Tohoku Fukushi University
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Hirose Takuo
Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine
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Yatabe Megumi
Division of Cell Biology and Histology, Department of Anatomy, Jichi Medical University School of Medicine
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Fujiwara Ken
Division of Cell Biology and Histology, Department of Anatomy, Jichi Medical University School of Medicine
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Yashiro Takashi
Division of Cell Biology and Histology, Department of Anatomy, Jichi Medical University School of Medicine
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