EFFECT OF CYCLIC DIPEPTIDES CONTAINING HISTIDINE ON PENTOBARBITAL NARCOSIS

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概要

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• We examined the effect of cyclo (His-Pro) and its analogs on pentobarbital narcosis in mice. Cyclo (His-Pro), 500 nmol/mouse, administered via intracerebroventricular (i. c. v.) route significantly prolonged the sleeping time. Methylation of histidine in the structure of cyclo (His-Pro) did not increase the activity of cyclo (His-Pro). Some of other cyclo (His-Pro) analogs, of which proline was replaced with other amino acids, cyclo (His-Phe), cyclo (His-Tyr), cyclo (His-His) and cyclo (D-His-Leu) produced significant prologation of the sleeping time as compared with cyclo (His-Pro). These results suggest that cyclo (His-Pro) has opposing effect to that of thyrotropin releasing hormone (TRH) and the prolongation of pentobarbital narcosis by cyclic dipeptides might be caused by their central action.

• 公益社団法人日本薬学会の論文

著者

• TADANO Takeshi

  Department of Pharmacology, Tohoku Pharmaceutical University

• SAKURADA Tsukasa

  Department of Biochemistry, Daiichi College of Pharmaceutical Sciences

• KISARA Kensuke

  Department of Pharmacology, Tohoku College of Pharmacy

• Sakurada Tsukasa

  Department Of Biochemistry Daiichi College Of Pharmaceutical Sciences

• Tadano Takeshi

  東北薬科大学 薬理学

• Tadano Takeshi

  東北薬科大学 薬学部

• Tadano T

  Tohoku Pharmaceutical Univ. Sendai Jpn

• Kisara K

  Tohoku Coll. Pharmacy Sendai Jpn

• Sakurada T

  Daiichi Coll. Pharmaceutical Sci. Fukuoka

• Tadano T

  Dep. Of Pharmacology Tohoku Pharmaceutical Univ.

• Tadano Takeshi

  Department Of Pharmacology Tohoku Pharmaceutical University

• SUZUKI Tomoharu

  Department of Astronomy, University of Tokyo

• Suzuki Kenji

  Department Of Cardiology Kyoto Second Red Cross Hospital

• Sato Takumi

  東北薬科大学 薬理

• Tadano Takeshi

  Department Of Pharmacology Tohoku College Of Pharmacy

• Suzuki Kenji

  Department Of Biochemistry Tohoku College Of Pharmacy

• Suzuki Kenji

  Department Of Applied Physics Osaka University

• Suzuki Tomoharu

  Department Of Astronomy University Of Tokyo

• Suzuki Tomoharu

  Department Of Pharmacology Tohoku College Of Pharmacy

• SASAKI YUHSUKE

  Department of Biochemistry, Tohoku College of Pharmacy

• Kisara Kensuke

  Department Of Pharmacology Tohoku College Of Pharmacy

• Sasaki Yuhsuke

  Department Of Biochemistry Tohoku College Of Pharmacy

• Suzuki Kenji

  Department Of Anesthesia Kitakami Saiseikai Hospital

• KISARA Kensuke

  Department of Chemical Pharmacology Tohoku College of Pharmacy

• TADANO Takeshi

  Department of Chemical Pharmacology, Tohoku College of Pharmacy

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