EFFECTS OF MORPHINE ON SINGLE UNIT ACTIVITY OF THE AMYGDALA IN CATS
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概要
- 論文の詳細を見る
Single neuronal activity has been recorded extra-cellularly from the nucleus amygdaloideus centralis (pars lateralis) (Acl), the nucleus amygdaloideus centralis (pars medialis) (Acm), the nucleus amygdaloideus basalis (pars magnocellularis) (Abm), the nucleus amygdaloideus lateralis (AI), and the nucleus amygdaloideus basalis (pars parvocellularis) (Abp). The majority of the Acl, Acm, and Abm neurons were excited by nociceptive stimulation such as pinching the skin with serrated forceps and/or intraarterial injection of bradykinin. The nociceptive neurons were also driven by non-nociceptive stimulation such as tapping of deep tissues and bending hairs with an air-puff. Their receptive fields were large. After the intravenous administration of morphine, all nociceptive neurons became unresponsive to nociceptive stimuli, although they were driven by nonnociceptive stimuli. Intravenous naloxone antagonized the antinociceptive action of morphine. This suggests that morphine has selective and inhibitory effects on impulse transmission to these nociceptive neurons, and the amygdala, especially the Acl, Acm, and Abm, plays an important role in central nociceptive processing.
- 社団法人 日本薬理学会の論文
著者
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SAKURADA Shinobu
Department of Pharmacology, Tohoku College of Pharmacy
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KISARA Kensuke
Department of Pharmacology, Tohoku College of Pharmacy
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Sakurada Shinobu
Department Of Pharmacology Tohoku Pharmaceutical University
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Sakurada Tsukasa
Department Of Biochemistry Daiichi College Of Pharmaceutical Sciences
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Kisara Kensuke
Department Of Pharmacology Tohoku College Of Pharmacy
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Sato Takumi
Department Of Bioscience Tokyo University Of Agriculture
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Takahashi Norio
Department Of Aeronautical Engineering Faculty Of Engineering Kyoto University
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MIYAGAWA Toshiji
Department of Pharmacology, Tohoku College of Pharmacy
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ANDOH Ryuichiro
Department of Pharmacology, Tohoku College of Pharmacy
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SHIMA Keisetu
Department of Pharmacology, Tohoku College of Pharmacy
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MIYAGAWA Toshiji
Department of Chemical Pharmacology Tohoku College of Pharmacy
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KISARA Kensuke
Department of Chemical Pharmacology Tohoku College of Pharmacy
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SAKURADA Tsukasa
Department of Pharmacology, Tohoku College of Pharmacy
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SHIMA Keisetu
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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SATO Takumi
Department of Pharmacology, Tohoku College of Pharmacy
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ANDOH Ryuichiro
Department of Chemical Pharmacology Tohoku College of Pharmacy
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SAKURADA Shinobu
Department of Chemical Pharmacology Tohoku College of Pharmacy
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