2-Bromoethylamine, a Suicide Inhibitor of Tissue-Bound Semicarbazide-Sensitive Amine Oxidase
スポンサーリンク
概要
- 論文の詳細を見る
Various mammalian tissues contain plasma membrane−bound amine oxidase, termed semicarbazide−sensitive amine oxidase(SSAO).In the present study, 2−bromoethylamine has been studied with regard to inhibitory properties towards tissue−bound SSAO in rat lung.Without preincubation, 2−bromoethylamine was a competitive and reversible SSAO inhibitor with a Ki value of 2.5 μM.After preincubation, it time−dependently and non−competitively inhibited SSAO activity, probably by forming the covalently−bound enzyme−inhibitor adduct.The data presented suggest that 2−bromoethylamine may act as a suicide inhibitor of SSAO.
- 社団法人 日本薬理学会の論文
- 2000-06-01
著者
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TADANO Takeshi
Department of Pharmacology, Tohoku Pharmaceutical University
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KISARA Kensuke
Department of Pharmacology, Tohoku College of Pharmacy
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Tadano Takeshi
東北薬科大学 薬理学
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Tadano Takeshi
東北薬科大学 薬学部
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Tadano T
Tohoku Pharmaceutical Univ. Sendai Jpn
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Kisara Kensuke
石巻専修大学
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Tadano T
Dep. Of Pharmacology Tohoku Pharmaceutical Univ.
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Tadano Takeshi
Department Of Pharmacology Tohoku Pharmaceutical University
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Kisara Kensuke
Department Of Pharmacology Tohoku Pharmaceutical University
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Tadano Takeshi
Department Of Pharmacology Tohoku College Of Pharmacy
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TOYOSHIMA Yoshie
Department of Pharmacology
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KINEMUCHI Hiroyasu
Laboratory of Enzyme Pharmacology, Senshu University at Ishinomaki
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JINBO Masato
Laboratory of Enzyme Pharmacology, Senshu University at Ishinomaki
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TABATA Atsushi
Laboratory of Enzyme Pharmacology, Senshu University at Ishinomaki
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ARAI Yuichiro
Department of Pharmacology, School of Medicine, Showa University
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ORELAND Lars
Section of Pharmacology, Department of Neuroscience, Box 593, Biomedical Centre, Uppsala University
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Oreland L
Uppsala Univ. Swe
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Kinemuchi Hiroyasu
Laboratory Of Enzyme Pharmacology Senshu University At Ishinomaki
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Jinbo Masato
Laboratory Of Enzyme Pharmacology Senshu University At Ishinomaki
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Arai Yuichiro
Department Of Pharmacology School Of Medicine Showa University
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Tabata Atsushi
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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Tabata Atsushi
Laboratory Of Enzyme Pharmacology Senshu University At Ishinomaki
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Kisara Kensuke
Department Of Pharmacology Tohoku College Of Pharmacy
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Toyoshima Yoshie
Department Of Pharmacology School Of Medicine Showa University
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KISARA Kensuke
Department of Chemical Pharmacology Tohoku College of Pharmacy
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TADANO Takeshi
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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Arai Yuichiro
Department of Judotherapy, Faculty of Health Sciences, Tokyo Ariake University of Medical and Health Sciences
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