Enhanced Behavioral Response to Serotonin-Related Agonists in Postweaning Protein Malnourished Mice
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概要
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We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)1A receptor agonist 8-hydroxy-N,N-dipropyl-2-aminoteralin (8-OH-DPAT) and the 5-HT releaser d-fenfluramine. The number of head weaving responses induced by 8-OH-DPAT or d-fenfluramine in the PM mice was significantly increased compared with the control diet group. The effects of 8-OH-DPAT and d-fenfluramine were blocked by pretreatment with the selective 5-HT1A receptor antagonist WAY-100635 (0.01 mg/kg). However, postpubertal (56 d of age) mice fed with the PM diet did not show an enhancement of the 8-OH-DPAT-induced head weaving response. These results indicate the occurence of a supersensitivity of postsynaptic 5-HT1A receptor in the postweaning PM group. Moreover, they highlight the postweaning stage as a vulnerable period to malnutrition-induced alterations in central serotonergic systems.
- 公益社団法人 日本薬学会の論文
著者
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Tan-no Koichi
Department Of Pharmacology Tohoku College Of Pharmacy
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Tadano Takeshi
Department Of Pharmacology Tohoku College Of Pharmacy
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Nakagawasai Osamu
Department Of Pharmacology Tohoku Pharmaceutical University
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Hayashi Takafumi
Department Of Applied Chemistry Faculty Of Systems Engineering Wakayama University
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Sato Shoko
Department Of General Internal Medicine The Jikei University School Of Medicine
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Suzuki Tsuneyoshi
Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University
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Oikawa Atsuko
Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University
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Yaoita Fukie
Department of Pharmacology, Tohoku Pharmaceutical University
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Suzuki Tsuneyoshi
Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka
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Hayashi Takafumi
Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University
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TADANO Takeshi
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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