Studies on 5-fluoro-.ALPHA.-methyltryptamine and p-chloro-.BETA.-methylphenethylamine: Determination of the MAO-A or MAO-B selective inhibition in vitro.
スポンサーリンク
概要
- 論文の詳細を見る
To further clarify highly MAO-A- or -B-selective inhibitory properties of 5-fluoro-α-methyltryptamine (5-FMT) and p-chloro-β-methylphenethylamine (p-CMPEA), we determined the types and K<SUB>1</SUB> values of inhibition of rat brain MAO-A and -B activity in vitro. The kinetic data obtained showed that 5-FMT is a competitive MAO-A-selective inhibitor with about a 18, 000-fold higher sensitivity than MAO-B. In contrast, p-CMPEA is a competitive MAO-B-selective inhibitor with about a 620-fold higher sensitivity. Based on the present findings of highly MAO-A- or -B-selective inhibition, these two compounds might prove to be of value in in vivo studies.
- 公益社団法人 日本薬理学会の論文
著者
-
TOYOSHIMA Yoshie
Department of Pharmacology
-
ARAI Yuichiro
Department of Pharmacology, School of Medicine, Showa University
-
KINEMUCHI Hiroyasu
Department of Pharmacology, School of Medicine, Showa University
-
KISARA Kensuke
Department of Chemical Pharmacology Tohoku College of Pharmacy
-
TADANO Takeshi
Department of Pharmacology, Tohoku College of Pharmacy
-
TADANO Takeshi
Department of Chemical Pharmacology, Tohoku College of Pharmacy
-
Arai Yuichiro
Department of Judotherapy, Faculty of Health Sciences, Tokyo Ariake University of Medical and Health Sciences
関連論文
- Intrathecally Administered D-Cycloserine Produces Nociceptive Behavior Through the Activation of N-Methyl-D-aspartate Receptor Ion-Channel Complex Acting on the Glycine Recognition Site
- Anti-inflammatory Effect of Propolis through Inhibition of Nitric Oxide Production on Carrageenin-Induced Mouse Paw Edema(Pharmacology)
- ROLE OF MU-1 OPIOID RECEPTOR SUBTYPE ON MORPHINE-INDUCED ANTINOCICEPTION AGAINST RESPONSES TO MECHANICAL AND CHEMICAL NOXIOUS STIMULI IN MICE
- Effect of a Nutritive-Tonic Drink on Scopolamine-Induced Memory Impairment in Mice(Pharmacology)
- Inhibitory Effect of Propolis on the Growth of Human Leukemia U937 (Toxicology)
- POSSIBILITY OF A CENTRALLY ACTING TACHYKININ ANTAGONIST OF SUBSTANCE P FRAGMENTS AND ANALOGUES
- Changes in Ingestive Behavior Induced by Intracranial Injection of Spermine
- In vivo Screening test for antioxidant drugs using 8 Gy whole-body irradiated mice
- EFFECT OF DIMETHYL SULFOXIDE PRETREATMENT ON ACTIVITIES OF LIPID PEROXIDE FORMATION, SUPERROXIDE DISMUTASE AND GLUTATHIONE PEROXIDASE IN THE MOUSE LIVER AFTER WHOLE-BODY IRRADIATION
- 2-Bromoethylamine, a Suicide Inhibitor of Tissue-Bound Semicarbazide-Sensitive Amine Oxidase
- THE ROLE OF CENTRAL 5-HYDROXYTRYPTAMINE (5-HT) NEURONAL SYSTEMS IN p-HYDROXYAMPHETAMINE-INDUCED HEAD-TWITCH RESPONSE
- Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca^ channels
- Comparison of Cysteine and Serine Protease Inhibitors on Dynorphin B-Induced Antinociception in the Mouse Capsaicin Test
- EFFECT OF CYCLIC DIPEPTIDES CONTAINING HISTIDINE ON PENTOBARBITAL NARCOSIS
- Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
- Influence of Memantine on Brain Monoaminergic Neurotransmission Parameters in Mice: Neurochemical and Behavioral Study
- Effects of Atomoxetine on Levels of Monoamines and Related Substances in Discrete Brain Regions in Mice Intermittently Deprived of Rapid Eye Movement Sleep
- INHIBITION OF CARP LIVER MITOCHONDRIAL MONOAMINE OXIDASE BY SOME COMMONLY-USED DETERGENTS
- 5-HYDROXYTRYPTAMINE: A SUBSTRATE FOR RAT LIVER MITOCHONDRIAL MONOAMINE OXIDASE-A AND -B
- STUDIES ON MONOAMINE OXIDASE (REPORT 13) ISOLATION OF TWO DIFFERENT TYPES OF MONOAMINE OXIDASE FROM BEEF LIVER MITOCHONDRIA
- EFFECTS OF INTRAVENTRICULARLY ADMINISTERED POLYAMINES SPERMIDINE AND SPERMINE ON SLEEP-WAKEFULNESS CYCLES IN RATS
- EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATI OF ALIPHATIC DIAMINES ON INGESTIVE BEHAVIOR IN THE RAT
- STUDIES ON MONOAMINE OXIDASE (REPORT LXXVII) EFFECTS OF pH ON MAO IN RABBIT SERUM
- NFLUENCE OF LOCAL ADMINISTRATION OF SEROTONIN ON MITOCHONDRIAL ENZYME ACTIVITY OF RAT SKELETAL MUSCLE
- EFFECT OF TRIS (HYDROXYMETHYL) AMINOMETHANE ON AMINE OXIDASE ACTIVITY IN DOG BRAIN, LIVER AND SERUM AND IN HUMAN PLACENTA
- A SIMPLE DETERMINATION OF SEROTONIN, 5-HYDROXYINDOLEACETIC ACID AND 5-HYDROXYTRYPTOPHAN DECARBOXYLASE ACTIVITY IN RAT BRAIN AREAS AND PARALLEL CORRELATION AMONG THE LEVELS
- PHARMACOLOGICAL ACTIONS OF INTRACEREBRALLY ADMINISTERED POLYAMINES IN MICE
- EFFECTS OF BILATERAL OLFACTORY BULB ABLATIONS ON THE POLYAMINE LEVELS IN RAT BRAIN
- EFFECTS OF POLYAMINES ON THE CENTRAL NERVOUS SYSTEM
- CHANGES IN INGESTIVE BEHAVIOR, SERUM GLUCOSE AND FREE FATTY ACIDS CONCENTRATIONS IN RATS FOLLOWING INTRACEREBROVENTRICULAR INJECTION OF SPERMINE
- EFFECTS OF MORPHINE ON SINGLE UNIT ACTIVITY OF THE AMYGDALA IN CATS
- EFFECTS OF MORPHINE ON EVOKED POTENTIALS RECORDED FROM THE AMYGDALA BY TOOTH PULP STIMULATION IN CATS
- Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase II. Inhibition by α-Methylated Substrate-Analogue Monoamines, α-Methyltryptamine, α-Methylbenzylamine and Two Enantiomers of α-Methylbenzylamine
- Executive Functions of Postweaning Protein Malnutrition in Mice
- Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion
- Enhanced Behavioral Response to Serotonin-Related Agonists in Postweaning Protein Malnourished Mice
- Excitatory effects of dihydrocapsaicin on nociceptive neurons in the medial thalamus.
- Potentiating effects of prostaglandin E2 on bradykinin and capsaicin responses in medial thalamic nociceptive neurons.
- Comparison of the antinociceptive effect between the cyclic dipeptide cyclo (Tyr(Et)-homoarginine) and the linear dipeptide Boc-Tyr(Et)-homoarginine-OMe in rats.
- Head-twitches induced by p-hydroxyamphetamine in mice.
- Studies on 5-fluoro-.ALPHA.-methyltryptamine and p-chloro-.BETA.-methylphenethylamine: Determination of the MAO-A or MAO-B selective inhibition in vitro.
- Combined Low Calcium and Lack Magnesium Is a Risk Factor for Motor Deficit in Mice