EFFECTS OF INTRAVENTRICULARLY ADMINISTERED POLYAMINES SPERMIDINE AND SPERMINE ON SLEEP-WAKEFULNESS CYCLES IN RATS
スポンサーリンク
概要
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Freely moving rats with chronically implanted electrodes were used and the electroencephalogram (EEG) from the occipital cortex and the dorsal hippocampus, the electromyogram (EMG) and the electrooculogram (EOG) were simultaneously recorded. The REM (rapid eye movement) sleep stage was significantly shortened without a marked change of the Non-REM sleep from the 24th to the 32nd hr following injection of 40 μg of SPD. The waking stage significantly increased, and the Non-REM sleep and REM sleep markedly decreased immediately after the injection of 40 μg of SPM to the 8th, and from the 24th to the 32nd hr. The amount of total sleep significantly shortened from the 72nd to the 80th hr following injection of 40 μg of SPD. The administration of 40 μg of SPM significantly reduced the amount of total sleep in every period measured for 8 hr. Marked change was observed from the 24th to the 32nd hr following injection of 100 μg of PUT, and Non-REM sleep and total sleep produced a significant decrease. These results show that the intraventricular administration of polyamines including PUT inhibits the amount of normal sleep.
- 社団法人 日本薬理学会の論文
著者
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SAKURADA Tsukasa
Department of Biochemistry, Daiichi College of Pharmaceutical Sciences
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KISARA Kensuke
Department of Pharmacology, Tohoku College of Pharmacy
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Sakurada Tsukasa
Department Of Biochemistry Daiichi College Of Pharmaceutical Sciences
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Kisara Kensuke
Department Of Pharmacology Tohoku College Of Pharmacy
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KISARA Kensuke
Department of Chemical Pharmacology Tohoku College of Pharmacy
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SAKURADA Tsukasa
Department of Chennical Pharmacology, Tohoka College of Pharmacy
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