EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATI OF ALIPHATIC DIAMINES ON INGESTIVE BEHAVIOR IN THE RAT
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概要
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We examined the pharmacological effects of intracerebroven-tricularly administered aliphatic diamines on ingestive behavior in male rats adapted to a 4 hr per day feeding and drinking schedule. 1, 2-Ethanediamine (ETD), 1, 3-propanediamine (PRD), 1, 4-butanediamine (putrescine, PUT), 1, 5-pentanediamine (cadaverine, CAD) and 1, 6-hexanediamine (HED) suppressed feeding and drinking behavior in a dosedependent manner, but not unless a relatively high dose (over 80 μg) was given. The approximate anorectic potency was HED>CAD=PUT> ETD>PRD. A sedation was also produced in fairly good parallel to these alterations in feeding and drinking behavior. Thus, there appears to be a relationship between the length of the carbon chain and the potency of the pharmacological action, and these inhibitory effects on feeding and drinking behavior are probably not due to a specific action on the regulatory system for ingestive behavior, but rather to a nonspecific action.
- 社団法人 日本薬理学会の論文
著者
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KOHNO Hiroyuki
Department of Oncologic Pathology, Kanazawa Medical University
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SAKURADA Tsukasa
Department of Biochemistry, Daiichi College of Pharmaceutical Sciences
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KISARA Kensuke
Department of Pharmacology, Tohoku College of Pharmacy
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Sakurada Tsukasa
Department Of Biochemistry Daiichi College Of Pharmaceutical Sciences
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Sakurada Tsukasa
Department Of Radiopharmacy:department Of Pharmacology Tohoku College Of Pharmacy
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Sakurada Tsukasa
東北薬科大学
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Kisara Kensuke
Department Of Radiopharmacy:department Of Pharmacology Tohoku College Of Pharmacy
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Sakurada T
Daiichi Coll. Pharmaceutical Sci. Fukuoka
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Sato Takumi
東北薬科大学 薬理
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Kohno Hiroyuki
Department Of Radiopharmacy:department Of Pharmacology Tohoku College Of Pharmacy
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Kohno Hiroyuki
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Kisara Kensuke
Department Of Pharmacology Tohoku College Of Pharmacy
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KISARA Kensuke
Department of Chemical Pharmacology Tohoku College of Pharmacy
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KOHNO Hiroyuki
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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