Preventive Effects of Powdered Broccoli Sprout on Azoxymethane-induced Rat Colonic Aberrant Crypt Foci
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概要
- 論文の詳細を見る
The modifying effects of dietary feeding of powdered broccoli sprout (PBS), which contained a high concentration of sulforaphane, on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were investigated in male F344 rats. We also determined the influence of PBS on proliferating cell nuclear antigen (PCNA) index in “normal-appearing” crypts from rats treated with AOM and/or PBS, and activities of detoxifying enzymes of cytochrome P450 (CYP) and glutathione S-transferase (GST) in the liver. Rats were given two weekly subcutaneous injections of AOM (20 mg/kg body wt) to produce ACF. They also received experimental diets containing PBS at a dose of 20 or 100 ppm for 4 weeks, starting 1 week before the first dose of AOM. AOM exposure induced a substantial number of ACF (106 ± 10) at the end of the study (week 4). Dietary administration of PBS caused significant reduction in the frequency of ACF: 20 ppm PBS, 56 ± 11 (47% reduction, P<0.001) and 100 ppm PBS, 64 ± 23 (40% reduction, P<0.001). Immunohistochemically, PBS administration at both doses significantly lowered the PCNA index in “normal-appearing” crypts. In addition, feeding with PBS significantly reduced the activities of CYP 2B and CYP 3A, and slightly increased GST activity in the liver. These findings suggest a possible chemopreventive ability of PBS through alterations to the activities of cell proliferation in cryptal cells in the colon and activities of drug metabolizing enzymes in the liver.
- 日本毒性病理学会の論文
- 2004-06-30
著者
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SUZUKI Rikako
Department of Oncologic Pathology, Kanazawa Medical University
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KOHNO Hiroyuki
Department of Oncologic Pathology, Kanazawa Medical University
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SUGIE Shigeyuki
Department of Oncologic Pathology, Kanazawa Medical University
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TANAKA Takuji
The First Department of Pathology, Kanazawa Medical University
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KOHNO Hiroyuki
The First Department of Pathology, Kanazawa Medical University
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SUZUKI Rikako
The First Department of Pathology, Kanazawa Medical University
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Sugie S
Department Of Oncologic Pathology Kanazawa Medical University
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Sugie Shigeyuki
京都大学 農学研究科食品生物科学
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Sugie S
Kanazawa Medical Univ. Ishikawa
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Tanaka T
Faculty Of Fisheries Hokkaido University
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Tanaka Takuji
京都大学 農学研究科食品生物科学
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Suzuki R
Department Of Oncologic Pathology Kanazawa Medical University
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Suzuki Rikako
Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioscience Craduate School Of Fish
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SUGIE Shigeyuki
The First Department of Pathology, Kanazawa Medical University
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OKADA Tadashi
Oryza Oil & Fat Chemical Co. Ltd.
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Kohno H
Department Of Oncologic Pathology Kanazawa Medical University
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Tsukui Takayuki
Faculty Of Fisheries Sciences Hokkaido University
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Kohno Hiroyuki
The First Department Of Pathology Kanazawa Medical University
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Tanaka T
Endoscopic And Photodynamic Medicine Hamamatsu University School Of Medicine
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Tada Toshiji
Analytical Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tanaka Tatsuo
Endoscopic And Photodynamic Medicine Hamamatsu University School Of Medicine
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Okada Tadashi
Oryza Oil & Fat Chemical Co. Ltd.
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Tanaka Takuji
The First Department Of Pathology Kanazawa Medical University
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Kohno Hiroyuki
Department Of Serology Medical Research Institute Kanazawa Medical University
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