LACK OF INHIBITORY EFFECT OF BENZYL ISOTHIOCYANATE ON 2-AMINO-1-METHYL-6-PHENYLIMIDAZO [4,5-b]PYRIDINE (PhIP)-INDUCED MAMMARY CARCINOGENESIS IN RATS

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Modifying effects of benzyl isothiocyanate (BITC), a glucosinolate compound, were investigated on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female SD fats. One hundred twenty five female rats were divided into 4 groups. Starting at 6 weeks of age, rats were fed high fat diet containing 23.5% corn oil (Groups 1 and 4) or the experimental diet (high fat diet with 400 ppm BITC) (Groupd 2 and 3). At 7 weeks of age, Groups 1 and 2 were given PhIP (100 mg/kg body weight, 8 times for 16 days) by intragastric tube. One week after the final PhIP treatment, the experimental diet for Groups 2 and 3 switched to high fat diet. At the termination (31 weeks after the start of experiment), mammary adenocardinomas were recognized in Group 1 (PhIP alone) and Group 2 (PhIP + BITC). The incidende of neoplasms was 74.2% in Group 1, and 62.5% in Group 2. The multiplicity of them was 1.71±1.70 in Group 1, and 1.91±2.94 in Group 2. Mean sizes of tumors were 9.9±7.1 mm in Group 1, and 10.8±6.8 mm in Group 2. But no significant different as for tumors were available between the two groups. These results imply that the glucosinolate compound does not have clear inhibitory effects on PhIP-induced mammary carcinogenesis in rats.
日本トキシコロジー学会の論文
1996-08-25