Rapid induction of replicating DNA synthesis in response to 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline in rat hepatocytes
スポンサーリンク
概要
- 論文の詳細を見る
Genotoxicity and mitogenicity of 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline(MeIQ)were estimated by the simultaneous measurement of unscheduled DNA synthesis(UDS)and replicative DNA synthesis(RDS). A newly developed"cell culture insert DNA retention"(CDR)method was used and results were compared with those of a liver carcinogen, 2-acetylaminofluorene(2-AAF)and a tumor promoter, phenobarbital. An increase in UDS and RDS was observed in primary cultures of male ACI/N rat hepatocytes exposed to 10^<-8>〜10^<-5>M MeIQ, within four hours. This indicates that MeIQ-generated cell proliferation, as in the case of 2-AAF, is an early event in inhibition. This CDR approach suggests that the mitogenicity of MeIQ needs emphasis in multiple-step carcinogenesis.
- 日本環境変異原学会の論文
- 1998-04-10
著者
-
SUGIE Shigeyuki
Department of Oncologic Pathology, Kanazawa Medical University
-
Mori Hideki
Department of Biological Science, Graduate School of Science, Osaka Prefecture University
-
Mori H
Division Of Pathology National Institute Of Health Sciences
-
WAKABAYASHI Keiji
Cancer Prevention Division, National Cancer Center Research Institute
-
Sugie S
Department Of Oncologic Pathology Kanazawa Medical University
-
Sugie Shigeyuki
京都大学 農学研究科食品生物科学
-
Sugie S
Kanazawa Medical Univ. Ishikawa
-
Okumura Ataru
Department of Pathology, Gifu University School of Medicine
-
Wakabayashi Keiji
Cancer Prevention Basic Research Project National Cancer Center Research Institute
-
Wakabayashi K
National Cancer Center Res. Inst. Tokyo
-
Okumura Ataru
Department Of Endocrinological Metabolism Anjo Kosei Hospital
-
Okumura Ataru
Department Of Pathology Gifu University School Of Medicine
-
Sugie Shigeyuki
Department Of Oncologic Pathology Kanazawa Medical University
-
Mori Hideki
Department Of Anatomy Okayama University Medical School
関連論文
- A rolled sheet of collagen gel with cultured Schwann cells : Model of nerve conduit to enhance neurite growth(CELL AND TISSUE ENGINEERING)
- A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
- Lack of Enhancing Effect of Lauric Acid on the Development of Aberrant Crypt Foci in Male ICR Mice Treated with Azoxymethane and Dextran Sodium Sulfate
- Effect of microwell chip structure on cell microsphere production of various animal cells(CELL AND TISSUE ENGINEERING)
- Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
- Tumor formation is correlated with expression of β-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice
- A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
- Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
- Carcinoid tumor in the female urethral orifice : Rare case report and a review of the literature
- Induction of Apoptosis by Sulindac in Azoxymethane-induced Possible Colonic Premaligmant Lesions in Rats
- Chemopreventive Effects of a Flavonoid Antioxidant Silymarin on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Urinary Bladder Carcinogenesis in Male ICR Mice
- A rolled sheet of collagen gel with cultured Schwann cells : Model of nerve conduit to enhance neurite growth
- Suppressive Effect of Irsogladine Maleate on Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis in Male F344 Rats
- Mechanistic Insights of Carcinogenesis and Anti-carcinogenesis by Dietary Compounds
- Preventive Effects of Powdered Broccoli Sprout on Azoxymethane-induced Rat Colonic Aberrant Crypt Foci
- Chemopreventive Effects of Scordinin on Diethylnitrosamine and Phenobarbital-induced Hepatocarcinogenesis in Male F344 Rats
- Dietary Prevention of Azoxymethane-Induced Colon Carcinogenesis with Rice-Germ in F344 Rats.
- β-Catenin (Ctnnb1) Gene Mutations in Diethylnitrosamine (DEN)-induced Liver Tumors in Male F344 Rats
- Modulating Effects of Diets High in ω-3 and ω-6 Fatty Acids in Initiation and Postinitiation Stages of Diethylnitrosamine-induced Hepatocarcinogenesis in Rats
- Rapid induction of replicating DNA synthesis in response to 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline in rat hepatocytes
- Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon
- Inhibitory Effects of Diallyl Disulfide or Aspirin on 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced Mammary Carcinogenesis in Rats
- Suppressive Effects of S-Methyl Methanethiosulfonate on Promotion Stage of Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis Model
- Inhibitory Effect of Chlorophyllin on Diethylnitrosamine and Phenobarbital-induced Hepatocarcinogenesis in Male F344 Rats
- LACK OF INHIBITORY EFFECT OF BENZYL ISOTHIOCYANATE ON 2-AMINO-1-METHYL-6-PHENYLIMIDAZO [4,5-b]PYRIDINE (PhIP)-INDUCED MAMMARY CARCINOGENESIS IN RATS
- Suppressive Effects of Natural Antioxidants on Carcinogenesis in Digestive Organs (特別企画 〔日本環境変異原学会〕第24回大会ミニシンポジウム) -- (抗変異・抗発がんとラジカル)
- Chemopreventive Effects of Taurine on Diethylnitrosamine and Phenobarbitalinduced Hepatocarcinogenesis in Male F344 Rats
- In vitro osteogenic differentiation of HOS cells on two types of collagen gels(CELL AND TISSUE ENGINEERING)
- Chemoprevention of Azoxymethane-induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1'-Acetoxychavicol Acetate
- CARCINOGENICITY EXAMINATION OF 1-NITROPYRENE OXIDES AND RELATED CHEMICALS : LACK OF THEIR TUMORIGENIC EFFECTS IN A NEWBORN MICE ASSAY
- Suppression of Occurrence and Advancement of β-Catenin-accumulated Crypts, Possible Premalignant Lesions of Colon Cancer, by Selective Cyclooxygenase-2 Inhibitor, Celecoxib
- Enzyme cytology of alkaline phosphatase in lung cancer
- Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate
- Lack of modifying effects of 4-tert-octylphenol and benzyl butyl phthalate on 3, 2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
- Chemopreventive Effect of Curcumin on N-Nitrosomethylbenzylamine-induced Esophageal Carcinogenesis in Rats
- Chemoprevention by Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP)-induced Mammary Gland Carcinogenesis in Rats
- Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells
- Preventive Effect of Juzen-taiho-to on Endometrial Carcinogenesis in Mice Is Based on Shimotsu-to Constituent(Pharmacology)
- Inhibitory Effects of Toremifene on N-Methyl-N-nitrosourea and Estradiol-17β-induced Endometrial Carcinogenesis in Mice
- Preventive Effects of Isoflavones, Genistein and Daidzein, on Estradiol-17β-related Endometrial Carcinogenesis in Mice
- Effects of Tamoxifen on Endometrial Carcinogenesis in Mice
- Inhibitory Effects of Medroxyprogesterone Acetate on Mouse Endometrial Carcinogenesis
- Chemoprevention of Carcinogenesis by Organoselenium Compounds
- PHASE EQUILIBRIA AND SIMULATION METHOD FOR HETEROGENEOUS AZEOTROPIC DISTILLATION
- Calculation of Three-Phase Flash and Partial Condensation for Ternary Systems
- A Method of Calculating Multistage Liquid-Liquid Extraction for Ternary Systems
- Observational Examination of Aggregation and Migration during Early Phase of Neurosphere Culture of Mouse Neural Stem Cells(CELL AND TISSUE ENGINEERING)
- Image Cytometry for Analyzing Regional Distribution of Cells Inside Human Neurospheres(CELL AND TISSUE ENGINEERING)
- High-throughput screening of differentially expressed proteins in drug treated cells using SELDI-TOFMS(Proceedings of the 32nd Annual Meeting)
- Development of gene and protein expression screening-based toxicogenomics system using human primary normal neuronal cells (Proceedings of the 32nd Annual Meeting)
- Effects of Heparin and Its 6-O-and 2-O-Desulfated Derivatives with Low Anticoagulant Activity on Proliferation of Human Neural Stem/Progenitor Cells(CELL AND TISSUE ENGINEERING, Advances in Biomedical Science and Engineering)
- Functional expression of ABCG2 transporter in human neural stem/progenitor cells
- SUPPRESSIVE EFFECTS OF CHLOROGENIC ACID ON N-METHYL-N-NITROSOUREA-INDUCED GLANDULAR STOMACH CARCINOGENESIS IN MALE F344 RATS
- Inhibitory Effect of NS-398, a Selective Cyclooxygenase-2 Inhibitor, on Azoxymethane-induced Aberrant Crypt Foci in Colon Carcinogenesis of F344 Rats
- Genotoxicity of a Variety of Azobenzene and Aminoazobenzene Compounds in the Hepatocyte/DNA Repair Test and the Salmonella/Mutagenicity Test.
- The Effects of a Novel Cyclohexane Dicarboximide Derivative, ST-6,on Hypoxia/Reoxygenation Injury in Perfused Rat Heart
- INFLUENCES OF LONG-TERM ADMINISTRATION OF 24R, 25-DIHYDROXYVITAMIN D_3, A VITAMIN D_3 DERIVATIVE, IN RATS
- LACK OF PROMOTIVE EFFECT OF QUERCETIN ON METHYLAZOXYMETHANOL ACETATE CARCINOGENESIS IN RATS
- Simplified Heat and Mass Transfer Model for Distillation Column Simulation
- Total Reflux Simulation of Packed Column Distillation
- PACKED COLUMN DISTILLATION SIMULATION WITH A RATE-BASED METHOD
- THERMODYNAMIC FACTORS DERIVED FROM GROUP CONTRIBUTION ACTIVITY COEFFICIENT MODELS
- Chemopreventive Effect of N-(2-Cyclohexyloxy-4-nitrophenyl)methane Sulfonamide (NS-398), a Selective Cyclooxygenase-2 Inhibitor, in Rat Colon Carcinogenesis Induced by Azoxymethane
- Apoptosis Induced by NS-398, a Selective Cyclooxygenase-2 Inhibitor, in Human Colorectal Cancer Cell Lines
- Chemopreventive Effects of Plant Derived Phenolic, Organosulfur and Other Compounds on Carcinogenesis in Digestive Organs
- Expression of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) mRNA in Rat Testes
- Singular Finite Elements for the Die-Swell Simulation of Viscoelastic Fluids
- Practical Correlation of Excess Molar Volumes of Binary, Ternary and Quaternary Mixtures of Water, Methanol, Ethanol and 1-Propanol by an NRTL-Type Equation
- Application of a Singular/Decoupled Finite Element Method to the Viscoelastic Die-swell Flow Simulation
- NUMERICAL ANALYSIS OF TURBULENT FLOW AND HEAT TRANSFER IN PARALLEL PLATES ATTACHED WITH TURBULENCE PROMOTERS AT REGULAR INTERVALS ON LOWER SURFACE
- P590 THE CHANGE OF PLASMA BRAIN NATRIURETIC PERTIDE (BP), PLASMA CATECHOLAMINE (CA) AND AUTONOMIC NEVOUS ACTIVITY (ANA) IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (AMI)
- P414 THE RELATIONSHIP BETWEEN CIRCADIAN VARIATION OF TOTAL VASCULAR TONE(TVT)AND MAGNESIUM(MG)DEFICIENCY IN THE BODY IN PATIENTS WITH VASOSPASTIC ANGINA
- -P063- CIRCADIAN VARIATION OF TOTAL VASCULAR TONE(TVT)IN PATIENTS WITH VASOSPASTIC ANGINA PECTORIS(VSA) : STUDY ON BEFORE AND AFTER ADMINISTRATION OF CALCIUM CHANNEL BLOCKER(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOC
- THE RELATIONSHIP BETWEEN CIRCADIAN VARIATION OF TOTAL VASCULAR TONE (TVT) AND AUTONOMIC NERVOUS ACTIVITY (ANA) IN PATIENTS WITH VASOSPASTIC ANGINA PECTORIS
- THE RELATIONSHIP BETWEEN THE CIRCADIAN VARIATION OF TOTAL VASCULAR TONE (TVT) AND AUTONOMIC NERVOUS ACTIVITY (ANA) IN PATIENTS WITH ESSENTIAL HYPERTENSION
- THE RELATIONSHIP BETWEEN THE CIRCADIAN VARIATION OF TOTAL VASCULAR TONE (TVT) AND AUTONOMIC NERVOUS ACTIVITY (ANA) IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (AMI) THOUGHT TO BE CAUSED BY CORONARY VASOSPASM (CV)
- THE RELATIONSHIP BETWEEN CIRCADIAN VARIATION OF TOTAL VASCULAR TONE (TVT) AND SYMPATHETIC NERVOUS ACTIVITY (SNA) IN PATIENTS WITH CHRONIC HEART FAILURE
- THE RELATIONSHIP BETWEEN THE CIRCADIAN VARIATION OF TOTAL VASCULAR TONE(TVT)AND THE SYMPATHETIC NERVOUS ACTIVITY(SNA)IN PATIENTS WITHE VASOSPASTIC ANGINA PECTORIS(VAP)
- STUDY ON THE CIRCADIAN VARIATION OF TOTAL VASCULAR TONE(TVT)IN PATIENTS WITHE ACUTE MYOCARDIAL INFARCTION(AMI)THOUGHT TO BE CAUSED BY CORONARY VASOSPASM(CV)
- THE PROSTAGLANDINS SYNTHESIS IN RAT'S AORTA AND THEIR ROLE IN THE REGULATION OF BLOOD PRESSURE : Pathophysiology, Vessel : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- TWO-DIMENSIONAL ECHOCARDIOGRAPHIC MEASUREMENT OF LEFT VENTRICULAR VOLUME : New Techniques, Echocardiography II : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PE-073 Utility of brain natriuretic peptide (BNP) in prediction of stable coronary ischemia(Angina Pectoris, Clinical 1 (IHD) : PE13)(Poster Session (English))
- Six-Month Follow-Up of Takotsubo Cardiomyopathy with I-123-β-Metyl-Iodophenyl Pentadecanoic Acid and I-123-Meta-Iodobenzyl-Guanidine Myocardial Scintigraphy
- Genotoxicity of Carcinogenic N-Nitrosopropylamine Derivatives in the Hepatocyte Primary Culture/DNA-Repair Test.
- Expression of phospholipid hydroperoxide glutathione peroxidase(PHGPx)mRNA in rat testes.
- ADDITIONAL SURVEY ON GENOTOXICITY OF NATURAL ANTHRAQUINONES IN THE HEPATOCYTE PRIMARY CULTURE/DNA REPAIR ASSAY
- Hepatocarcinogenic Activities of Hydorxymethyl Derivatives of 4-(N, N-Dimethylamino)azobenzene in ACI/N Rats.
- MEASUREMENT OF UNSCHEDULED DNA SYNTHESIS ON ALKYLATING CARCINOGENS IN RAT INTESTINAL MUCOSAL CELLS FROM DIFFERENT SITES
- A MODIFIED BROYDEN-HOUSEHOLDER ALGORITHM FOR SOLVING MULTICOMPONENT DISTILLATION PROBLEMS
- PJ-350 Noncontrast T1-weighted Vessel Wall Imaging : Usefulness as an Additional Triage Tool to Detect Vulnerable Patients with Acute Chest Pain(MRI/MRA(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- OE-384 Phrenic Nerve Detection : Comparison of Cardiovascular Magnetic Resonance with Multidetector Computed Tomography(Arrhythmia, therapy(04)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- SOME TOXIC PROPERTIES OF A CARCINOGENIC PYRROLIZIDINE ALKALOID, PETASITENINE
- Effect of mixing condition of additives on the solidification of green body by gelcasting method
- A STAGEWISE ALGORITHM FOR MULTICOMPONENT MULTISTAGE BATCH DISTILLATION CALCULATION
- GA-based Task Allocation by Throughput Prediction
- Simultaneous Measurement of Unscheduled and Replicating DNA Synthesis by Means of a New Cell Culture Insert DNA Retention Method: Rapid Induction of Replicating DNA Synthesis in Response to Genotoxic Carcinogens
- Ciliary Body Schwannoma Successfully Treated by Local Resection
- Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus
- ACCELERATING CONVERGENCE IN SUCCESSIVE RELAXATION ALGORITHM FOR MULTICOMPONENT DISTILLATION CALCULATION
- In vitro osteogenic differentiation of HOS cells on two types of collagen gels