In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH)
スポンサーリンク
概要
- 論文の詳細を見る
Mutagenicity of fucoxanthinol (FXOH), the major compound after oral ingestion of fucoxanthin (FX), was evaluated by in vitro Ames test, and of FX by in vivo micronucleus test. In in vitro Ames test, bacterial reverse mutation was examined by using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537, and Escherichia coli WP2uvrA/pKM101, with or without metabolic activation by S9 mix in the preincubation method, and mutagenicity of FXOH was found to be negative in all cases. In in vivo micronucleus test, mice were orally administered with FX at doses of 500, 1,000 and 2,000mg/kg, and the bone marrow cells were taken 24hr after the administration to observe the incidence of micronucleus cells, and mutagenicity of FX was found to be negative at all doses. Based on the data of the present study it can be presumed that orally administered FX is a safe compound in terms of mutagenicity under the experimental conditions employed here.
- 2009-12-01
著者
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Tanaka T
Faculty Of Fisheries Hokkaido University
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Tanaka Takuji
京都大学 農学研究科食品生物科学
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Sato Emiko
New Industry Creation Hatchery Center Tohoku University
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Kohno Masahiro
New Industry Creation Hatchery Center, Tohoku University
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HOSOKAWA Masashi
Faculty of Fisheries, Hokkaido University
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Hosokawa M
Faculty Of Fisheries Sciences Hokkaido University
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Tsukui Takayuki
Faculty Of Fisheries Sciences Hokkaido University
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Tanaka T
Endoscopic And Photodynamic Medicine Hamamatsu University School Of Medicine
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Niwano Yoshimi
Research Center For Functional Food Materials Sunny Health Holdings Co. Ltd. Saito Biotechnology Inc
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Kohno Masahiro
New Ind. Creation Hatchery Center Tohoku Univ.
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MIYASHITA KAZUO
Faculty of Fisheries Sciences, Hokkaido University
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Beppu Fumiaki
Research Center for Functional Food Materials, Sunny Health Holdings Co., Ltd., Saito Biotechnology
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Beppu Fumiaki
Sunny Health Holdings Co. Ltd. Osaka Jpn
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Beppu Fumiaki
Research Center For Functional Food Materials Sunny Health Holdings Co. Ltd. Saito Biotechnology Inc
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Tada Toshiji
Analytical Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tanaka Tatsuo
Endoscopic And Photodynamic Medicine Hamamatsu University School Of Medicine
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Hosokawa Masashi
Faculty Of Fisheries Hokkaido University
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Hosokawa Masashi
Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioscience Craduate School Of Fish
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Miyashita Kazuo
Faculty Of Fisheries Hokkaido University
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Tanaka Takuji
Faculty Of Fisheries Hokkaido University
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Kamibayashi Masato
Faculty Of Fisheries Hokkaido University
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Niwano Yoshimi
Tohoku University Graduate School Of Dentistry Laboratory For Redox Regulation
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Niwano Yoshimi
Tohoku University Graduate School Of Dentistry
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