Evaluation of the potential biological toxicities of aqueous extracts from red tide phytoplankton cultures in in vitro and in vivo systems

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概要

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• The biological toxic potentials of aqueous extracts from the dinophycean flagellates Gymnodinium impudicum and Alexandrium affine and the raphidophycean flagellate Chattonella ovata were examined in both in vitro and in vivo systems. Interestingly, the extract from A. affine was the only one that showed potent cytotoxicities towards HeLa, Vero, and Neuro-2a cells in a concentration- dependent manner. Mice given intraperitoneal injections of the extracts revealed that none of the extracts exhibited serious toxicities in mice. However, temporal body weight loss was observed in the mice injected with the extract from A. affine during the early stage, and the dramatic enlargement of spleens was also observed in the mice on the 7th day after injection. Since A. affine extract showed potent hemolytic activity in vitro towards mouse erythrocytes, hemolytic anemia may be a possible mechanism responsible for the splenomegaly in the mice injected with A. affine extract. Similar marginal effects were observed in the mice injected with the extract from C. ovata; however, no significant toxic or detrimental effects were detected in the mice injected with the extract from G. impudicum. These results suggest that the extract from G. impudicum may not be contaminated with detectable levels of biologically hazardous compounds and may be relatively safe compared with the other two extracts.

• The Japanese Society of Toxicology,日本トキシコロジー学会の論文
• 2010-08-01

著者

• Oda Tatsuya

  Div. Of Biochemistry Fac. Of Fisheries Nagasaki Univ.

• Oda T

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Yamasaki Yasuhiro

  Division of Biochemistry, Faculty of Fisheries, Nagasaki University

• YAMAGUCHI Kenichi

  Division of Biochemistry, Faculty of Fisheries, Nagasaki University

• Yamaguchi Kenichi

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Sato Emiko

  New Industry Creation Hatchery Center Tohoku University

• Oda Tatsuya

  New Industry Creation Hatchery Center Tohoku University

• Tatsuya Oda

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Niwano Yoshimi

  New Industry Creation Hatchery Center, Tohoku University

• Kohno Masahiro

  New Industry Creation Hatchery Center, Tohoku University

• Oda T

  Nagasaki Univ. Nagasaki Jpn

• Kim D

  Jeju Center Korea Basic Science Institute (kbsi)

• Oda T

  New Industry Creation Hatchery Center Tohoku University

• KIM Daekyung

  Jeju Center, Korea Basic Science Institute (KBSI)

• CHA Seon-Heui

  Jeju Center, Korea Basic Science Institute (KBSI)

• JIANG Zedong

  Division of Biochemistry, Faculty of Fisheries, Nagasaki University

• MATSUYAMA Yukihiko

  Seikai National Fisheries Research Institute

• YAMAGUCHI Kenichi

  New Industry Creation Hatchery Center, Tohoku University

• Jiang Zedong

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Cha Seon-heui

  Jeju Center Korea Basic Science Institute (kbsi)

• Okamoto Tarou

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Niwano Yoshimi

  New Ind. Creation Hatchery Center Tohoku Univ.

• Kohno Masahiro

  New Ind. Creation Hatchery Center Tohoku Univ.

• Kim Daekyung

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Yamamoto Yoshiko

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Kim Daekyung

  Jeju Center Korea Basic Science Institute (kbsi)

• Yamasaki Yasuhiro

  Division Of Biochemistry Faculty Of Fisheries Nagasaki University

• Oda T

  Faculty Of Fisheries Nagasaki University

• Matsuyama Y

  Seikai National Fisheries Research Institute

• Kamibayashi Masato

  Faculty Of Fisheries Hokkaido University

• Yamaguchi Kenichi

  New Industry Creation Hatchery Center Tohoku University

• Matsuyama Yukihiko

  Seikai National Fisheries Res. Inst.

• Niwano Yoshimi

  Tohoku University Graduate School Of Dentistry Laboratory For Redox Regulation

• Niwano Yoshimi

  Tohoku University Graduate School Of Dentistry

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