Detection and Pharmacokinetics of Alginate Oligosaccharides in Mouse Plasma and Urine after Oral Administration by a Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Method
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概要
- 論文の詳細を見る
A sensitive and simple liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed for the detection of alginate oligosaccharides (AOs) in mouse plasma and urine after oral administration. In an AO mixture, dimer, trimer, and tetramer were detected by LC-MS/MS equipped with an anion-exchange column with extremely high sensitivity. By this method, we detected certain levels of AOs in samples prepared from mouse plasma and urine after a single oral administration of the AO mixture. Based on a calibration curve made with an AO trimer peak area as a standard, the maximum plasma and urine concentrations of AOs were estimated to be 24.5 μg/ml at 5 min and 425.5 μg/ml at 30 min, respectively. These results suggest that the LC-MS/MS method is well suited to pharmacokinetic analysis of AOs in an in vivo system, and that some of orally administered AOs, at least from dimer to tetramer, are absorbed by digestive organs promptly, and that unaltered, these oligomers were excreted into an urine after a single oral administration to a mouse.
- 社団法人 日本農芸化学会の論文
- 2008-08-23
著者
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Oda Tatsuya
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Oda Tatsuya
Div. Of Biochemistry Fac. Of Fisheries Nagasaki Univ.
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Oda T
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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YAMAGUCHI Kenichi
Division of Biochemistry, Faculty of Fisheries, Nagasaki University
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YAMAMOTO Yoshiko
Division of Biochemistry, Faculty of Fisheries, Nagasaki University
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Yamaguchi Kenichi
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Tatsuya Oda
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Oda T
Nagasaki Univ. Nagasaki Jpn
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Oda T
New Industry Creation Hatchery Center Tohoku University
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Okamoto Tarou
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Nishikawa Toru
Nagasaki Prefectural Institute for Environment Research and Public Health
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Yokose Takeshi
Nagasaki Prefectural Institute for Environment Research and Public Health
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Yamamoto Yoshiko
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Yamasaki Yasuhiro
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Oda T
Faculty Of Fisheries Nagasaki University
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Yamaguchi Kenichi
New Industry Creation Hatchery Center Tohoku University
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YAMAGUCHI Kenichi
Division of Allergy and Rheumatology, St. Luke's International Hospital
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