Induction of TNF-α Production from Human Peripheral Blood Monocytes with β-1,3-Glucan Oligomer Prepared from Laminarin with β-1,3-Glucanase from Bacillus clausii NM-1
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概要
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We prepared a β-1,3-glucan oligomer (DP>_-4) from laminarin (DP : 25-30) derived from Laminaria digitata with β-1,3-glucanase, and examined its effect on human peripheral blood monocytes. Conditioned medium prepared by incubating monocytes (MC-CM) with the β-1,3-glucan oligomer showed strong inhibitory activity against the proliferation of human leukemic U937 cells. Since the β-1,3-glucan oligomer had no direct cytotoxic effect on U937 cells up to 1000μg/ml, the cytotoxicity of the MC-CM may be due to cytotoxic cytokines produced from monocytes stimulated by the β-1,3-glucan oligomer. On the other hand, the MC-CM prepared with original laminarin had little effect on the growth of U937 cells. The cytotoxicity of the MC-CM prepared with the β-1,3-glucan oligomer was significantly reduced by an anti-TNF-α antibody, but the anti-TNF-β antibody had no effect. Our results suggest that the enzymatically depolymerized β-1,3-glucan oligomer induces TNF-α production from human monocytes.
- 社団法人日本生物工学会の論文
- 2003-02-25
著者
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Oda Tatsuya
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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IWAMOTO Yoshiko
Division of Biochemistry, Faculty of Fisheries, Nagasaki University
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MIYANISHI NOBUMITSU
Department of Food Science and Technology, Tokyo University of Fisheries
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WATANABE ETSUO
Department of Food Science and Technology, Tokyo University of Fisheries
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Watanabe Etsuo
Department Of Food Science And Technology Tokyo University Of Fisheries
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Miyanishi Nobumitsu
Department Of Food Science And Technology Tokyo University Of Fisheries
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Iwamoto Yoshiko
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Miyanishi Nobumitsu
Department Of Food Life Sciences Toyo University
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WATANABE ETSUO
Department of Chemical Engineering, Gunma University
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