Biological Activities of Fucose-Containing Polysaccharide Ascophyllan Isolated from the Brown Alga Ascophyllum nodosum
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概要
- 論文の詳細を見る
A fucose-containing, sulfated polysaccharide ascophyllan was isolated from the brown alga Ascophyllum nodosum. Composition analysis demonstrated that ascophyllan mainly contains uronic acid, xylose, fucose, and sulfate half ester in approximately equimolecular proportions, which are evidently distinct from those of alginate and fucoidan. Ascophyllan inhibited the proliferation of U937 cells in a concentration-dependent manner, and DNA-fragmentation and typical apoptotic nuclear morphological changes were observed in the ascophyllan-treated cells. Furthermore, ascophyllan induced the secretion of tumor necrosis factor-α (TNF-α) and granulocyte colony-stimulating factor (G-CSF) from mouse macrophage cell line RAW264.7.
- 社団法人 日本農芸化学会の論文
- 2009-04-23
著者
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Oda Tatsuya
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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YAMAGUCHI Kenichi
Division of Biochemistry, Faculty of Fisheries, Nagasaki University
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Yamaguchi Kenichi
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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NAKAYASU Seiichirou
Research and Development Division, Hayashikane Sangyo Co., Ltd.
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SOEGIMA Ryo
Division of Biochemistry, Faculty of Fisheries, Nagasaki University
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Soegima Ryo
Division Of Biochemistry Faculty Of Fisheries Nagasaki University
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Nakayasu Seiichirou
Research And Development Division Hayashikane Sangyo Co. Ltd.
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