Presence of Peroxyradicals in Cigarette Smoke and the Scavenging Effect of Shikonin, a Naphthoquinone Pigment
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概要
- 論文の詳細を見る
Using a new method having been developed for the purpose of quantitative determination for peroxyradicals, the presence of peroxyradicals was proved in cigarette smoke. In brief, peroxyradicals in cigarette smoke were measured by ESR spectrometry coupled to non-reductive scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH). As a result, peroxyradicals were found to be major reactive oxygen species (ROS) since the concentration of peroxyradicals recovered from cigarette smoke was much higher than that of any of other ROS (superoxide and hydroxyl radical) and nitric oxide. Furthermore, several antioxidants (ascorbic acid, reduced glutathione, epigallocatechin gallate, shikonin) were examined for scavenging activity against peroxyradicals in the cigarette smoke. Among them shikonin alone exerted the scavenging activity, suggesting that shikonin is promising antioxidant for cigarette filters because of its effectiveness against broad range of ROS including peroxyradicals, heat resistance, nonvolatility and high affinity to the filter.
- 公益社団法人日本薬学会の論文
- 2005-07-01
著者
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Niwano Yoshimi
New Industry Creation Hatchery Center, Tohoku University
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Kohno Masahiro
New Industry Creation Hatchery Center, Tohoku University
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Kitagawa Akio
Business Development Division Sunny Health Co. Ltd.
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Niwano Yoshimi
New Ind. Creation Hatchery Center Tohoku Univ.
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Kohno Masahiro
New Ind. Creation Hatchery Center Tohoku Univ.
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NISHIZAWA Masahiro
New Industry Creation Hatchery Center, Tohoku University
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NISHIMURA Minemitsu
Business Development Division, Sunny Health Co., Ltd.
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Nishimura Minemitsu
Business Development Division Sunny Health Co. Ltd.
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Nishizawa Masahiro
New Industry Creation Hatchery Center Tohoku University
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Nishizawa Masahiro
New Ind. Creation Hatchery Center Tohoku Univ.
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