Effects of Atomoxetine on Levels of Monoamines and Related Substances in Discrete Brain Regions in Mice Intermittently Deprived of Rapid Eye Movement Sleep
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概要
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An imbalance between noradrenergic and dopaminergic systems is implicated in hyperactivity disorders, such as attention deficit/hyperactivity disorder (ADHD). We previously showed that the explosive jumping behavior elicited by intermittent rapid eye movement sleep deprivation (REMSD) may serve as a useful model of ADHD (see [Biogenic Amines, 20, 99—111]). Here, we investigated whether intermittent REMSD might cause changes in monoamine turnover in the mouse forebrain. Our main findings were as follows. Intermittent REMSD led to a significant decrease in dopamine turnover and a significant increase in noradrenaline turnover in the frontal cortex. The latter effect, but not the former, was attenuated by atomoxetine, which is used clinically to treat ADHD symptoms. These results suggest (a) that intermittent REMSD induces hypernoradrenergic and hypodopaminergic states within the frontal cortex, and (b) that the therapeutic effects of atomoxetine may include an inhibition of this hypernoradrenergic state.
著者
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NIIJIMA Fukie
Department of Pharmacology, Tohoku Pharmaceutical University
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Tan-no Koichi
Department Of Pharmacology Tohoku College Of Pharmacy
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Tadano Takeshi
Department Of Pharmacology Tohoku College Of Pharmacy
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Watanabe Hiromi
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Nakagawasai Osamu
Department Of Pharmacology Tohoku Pharmaceutical University
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Arai Yuichiro
Department Of Pharmacology School Of Medicine Showa University
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Saito Hiroko
Laboratory of Pharmacology, Faculty of Pharmaceutical Science, Aomori University
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Murai Shigeo
Laboratory of Pharmacology, Faculty of Pharmaceutical Science, Aomori University
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Hiraga Hajime
Department of Pharmacology, Tohoku Pharmaceutical University
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Niijima Fukie
Dep. Of Pharmacology Tohoku Pharmaceutical Univ.
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TADANO Takeshi
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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Arai Yuichiro
Department of Judotherapy, Faculty of Health Sciences, Tokyo Ariake University of Medical and Health Sciences
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