Diffuse Parenchymal Pulmonary Amyloidosis Showing an Objective Response to Bortezomib-based Chemotherapy

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概要

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• A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

• 一般社団法人 日本内科学会の論文

著者

• RAI Kammei

  Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of

• Watanabe Hiromi

  Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine

• Kameyama Nobuhisa

  Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro

• Sunami Kazutaka

  Department Of Hematology National Hospital Organization Okayama Medical Center

• Sato Ken

  Department Of Applied Physics Tokyo University Of Agriculture And Technology

• Fujiwara Keiichi

  Department Of Cardiovascular Surgery Amagasaki Hospital

• Matsushita Mizuho

  Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan

• Sunami Kazutaka

  Department of Hematology, National Hospital Organization Okayama Medical Center, Japan

• Higo Hisao

  Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan

• Makimoto Go

  Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan

• Inomata Tomoko

  Department of Hematology, National Hospital Organization Okayama Medical Center, Japan

• Shibayama Takuo

  Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan

• Rai Kammei

  Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan

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