Effects of Angiotensin Receptor Blocker on Oxidative Stress and Cardio-Renal Function in Streptozotocin-Induced Diabetic Rats

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概要

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• The important role of renin-angiotensin-aldosterone system blockade in the treatment of diabetes-induced cardiomyopathy and nephropathy has been clearly established. The present study examined the effect of angiotensin II type 1 receptor blocker (ARB) losartan on oxidative stress and cardio-renal function in streptozotocin (STZ)-induced diabetic rats. Losartan treatment resulted in improvement of myocardial function and suppressed cardiac and renal fibrosis compared with the diabetic group. Losartan treatment also down-regulated transforming growth factor-β1 expression and attenuated the increased expression levels of p22phox and Nox4. Blood urea nitrogen (BUN) and urinary protein levels were increased significantly in the diabetic group. Losartan treatment significantly reduced proteinuria but not BUN level. Moreover, the elevated level of malondialdehyde in both heart and kidney were significantly reduced in the losartan-treated group compared with the diabetic group. These results provided evidence that oxidative stress plays a major role in diabetic rats induced by STZ, and treatment with the ARB might be beneficial for preventing the development and progression of diabetic disease.

• 公益社団法人　日本薬学会の論文

著者

• Watanabe Kenichi

  Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences

• Watanabe Kenichi

  新潟大学 医歯学総合研究科循環器学

• Aizawa Yoshifusa

  First Department of Internal Medicine, Niigata University School of Medicine

• Kodama Makoto

  First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine

• VEERAVEEDU Punniyakoti

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharm

• THANDAVARAYAN Rajarajan

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharm

• MA Meilei

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharm

• Suzuki Kenji

  Department Of Cardiology Kyoto Second Red Cross Hospital

• Ma Meilei

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Watanabe Kenichi

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Suzuki Kenji

  Department Of Applied Physics Osaka University

• TACHIKAWA Hitoshi

  First Department of Medicine, Niigata University School of Medicine

• Veeraveedu Punniyakoti

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Thandavarayan Rajarajan

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Arozal Wawaimuli

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharm

• Wawaimuli Arozal

  Department Of Clinical Pharmacology Niigata University Of Pharmacy And Applied Life Sciences

• Watanabe Kenichi

  Division Of Cardiology Tsubame Rosai Hospital

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Kodama Makoto

  First Dep. Of Medicine Graduate School Of Medical And Dental Sciences Niigata Univ.

• Suzuki Kenji

  Department Of Anesthesia Kitakami Saiseikai Hospital

• Aizawa Yoshifusa

  First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences

• Watanabe Kenichi

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences

• Kodama Makoto

  First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences

• TACHIKAWA Hitoshi

  First Department of Internal Medicine, Radioisotope Center, Niigata University Graduate School of Medicine:Department of Clinical Pharmacology, Niigata College of Pharmacy

• Veeraveedu Punniyakoti

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences

• Tachikawa Hitoshi

  First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences

• Arozal Wawaimuli

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

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