Effects of Edaravone in Heart of Aged Rats after Cerebral Ischemia-Reperfusion Injury(Pharmacology)

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概要

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• Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) has potent effects in the brain as a free radical scavenger in ischemia-reperfusion (IR) injuries. However, whether this free radical scavenger can prevent myocardial injury after cerebral IR is not clear. The aim of the present study was to investigate the effect of edaravone against oxidative damage in brain-to-heart signaling triggered by IR injury and its possible mechanism. In this study, the expression of glutathione peroxidase (GSHPx) and protein carbonyl content was examined to evaluate oxidative stress. The activation of mitogen-activated protein kinases (MAPKs) was also examined. Terminal deoxynucleotidyl transferase nick-end labeling (TUNEL) analysis was performed to estimate cardiomyocytes cell death. After edaravone treatment there was a mild increase in activities of GSHPx in cardiomyocytes; however, there was a decrease in protein carbonyl content. p38 MAPK activity was inhibited by edaravone treatment in comparison with the vehicle group in myocardium. These results were further complemented by a significant reduction of TUNEL-positive cells in the heart sections. Our results demonstrate that edaravone provides ameliorative effects in the myocardium after cerebral IR injury by differentially modulating MAPK's activity, thus reducing the oxidative stress state.

• 公益社団法人日本薬学会の論文
• 2007-03-01

著者

• Watanabe Kenichi

  Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences

• Watanabe Kenichi

  新潟大学 医歯学総合研究科循環器学

• Aizawa Yoshifusa

  First Department of Internal Medicine, Niigata University School of Medicine

• Kodama Makoto

  First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine

• Kodama Makoto

  新潟大学 医歯学総合研究科循環器学

• MA Meilei

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharm

• Ma Meilei

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Watanabe Kenichi

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• 相澤 好治

  北里大学・医・衛生公衛

• WEN Juan

  Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Llfe Sciences

• Wen Juan

  Department Of Clinical Pharmacology Niigata University Of Pharmacy And Applied Llfe Sciences

• Watanabe K

  Cardiovascular Division Tsubame Rosai Hospital

• Watanabe Kenichi

  Division Of Cardiology Tsubame Rosai Hospital

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Kodama Makoto

  First Dep. Of Medicine Graduate School Of Medical And Dental Sciences Niigata Univ.

• Aizawa Yoshifusa

  Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical An

• Watanabe Kenichi

  燕労災病院

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

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