Suppression of Myocardial Inflammation Using Suramin, A Growth Factor Blocker
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概要
- 論文の詳細を見る
Autoimmune myocardial injuries are involved in the pathogenesis of myocarditis and dilated cardiomyopathy, but effective strategies for treating myocardial inflammation have not yet been established. The present study investigated the effects of suramin, a growth factor blocker, on experimental autoimmune myocarditis (EAM) in rats. Lewis rats were immunized with cardiac myosin and placed into one of 4 groups: every 72h for 1 month the control group (C) was subcutaneously injected with saline; group L received 4 mg/kg of suramin; group M, 10mg/kg; group H, 40mg/kg. The heart weight/body weight ratios of the M and H groups were significantly lower than that of the C group. Macroscopic and microscopic scores for myocarditis were reduced in the M and H groups. The expression of transforming growth factor (TGF)-β1 mRNA in the heart was significantly decreased in the M and H groups compared with the C. In the next experiment, we investigated the effects of suramin on the cytokine milieu in EAM. The serum level of interleukin-10 on day 15 was significantly increased by suramin treatment. Furthermore, suramin increased the number of T cells with Th2 function in the popliteal lymph nodes. Suramin suppressed myocardial inflammation in EAM and was associated with modulation of the Th1/Th2 cytokine milieu and reduced TGF-β1 expression in the heart.
- 社団法人日本循環器学会の論文
- 2002-03-20
著者
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Yamamoto Tadashi
Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sc
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Aizawa Yoshifusa
First Department of Internal Medicine, Niigata University School of Medicine
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Kodama Makoto
First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine
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FUSE Koichi
First Department of Internal Medicine, Niigata University School of Medicine
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Saikawa Takashi
First Department Of Internal Medicine Division Of Cardiology Niigata University School Of Medicine
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Fuse Koichi
Cardiovascular Center Tachikawa General Hospital
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Fuse Koichi
新潟大学 医学部第一内科
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Yamamoto Tadashi
Department Of Cardiology Kouseikai Hospital
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Shiono Takaaki
Niigata Rinko Hospital
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Hanawa H
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
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Hanawa Haruo
First Dept of Internal Medicine
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Shiono Takaaki
First Department of Internal Medicine, Niigata University School of Medicine
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Saigawa Takashi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
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Aizawa Yoshifusa
First Department Of Internal Medicine Niigata Universaity School Of Medicine
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Kodama Makoto
First Dep. Of Medicine Graduate School Of Medical And Dental Sciences Niigata Univ.
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Yamamoto Tadashi
Department Of Pathology Institute Of Nephrology Niigata University School Of Medicine
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Yamamoto Tadashi
Departmanets of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University
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HANAWA Haruo
First Department of Internal Medicine, Niigata University Scoolof Medicine
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HANAWA Haruo
First Department of Internal Medicine, Niigata University
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FUSE Koichi
First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.
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AIZAWA Yoshifusa
First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.
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