Involvement of Mast Cells in the Development of Fibrosis in Rats with Postmyocarditis Dilated Cardiomyopathy(Miscellaneous)

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概要

• 論文の詳細を見る

• Dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality. Occurrence of myocardial fibrosis is an important event in the ventricular remodeling process, which takes place during DCM. Mast cells are well known inflammatory cells implicated in various biological phenomena. The involvement of mast cells in the development of myocardial fibrosis of DCM in rats after autoimmune myocarditis remains unknown. Nine-week-old male Lewis rats were immunized with cardiac myosin and divided into vehicle treated (group V) and disodium cromoglycate (DSCG), a mast cell stabilizer (24mg/kg i.p.) treated (group DSCG) groups. The animals were sacrificed after 60d of immunization. The myocardium was excised and preserved for histopathology and protein analysis. Myocardial levels of transforming growth factor (TGF) β1 and collagen-III were quantified. Staining of mast cells was performed by toluidine blue. A significant correlation was obtained between myocardial fibrosis and cardiac mast cell density. DSCG reduced myocardial fibrosis besides preventing infiltration and degranulation of mast cells. Our findings confirm the active participation of mast cells in the progression of myocardial fibrosis in rats with postmyocarditis DCM.

• 公益社団法人日本薬学会の論文
• 2005-11-01

著者

• Watanabe Kenichi

  Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences

• Watanabe Kenichi

  新潟大学 医歯学総合研究科循環器学

• Aizawa Yoshifusa

  First Department of Internal Medicine, Niigata University School of Medicine

• Aizawa Y

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Kodama Makoto

  First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine

• MA Meilei

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharm

• Tachikawa Hitoshi

  Department of Cardiology, Niigata University School of Medicine

• Ma Meilei

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Watanabe Kenichi

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Palaniyandi Selvaraj

  Department Of Clinical Pharmacology Niigata University Of Pharmacy And Applied Life Sciences

• TACHIKAWA Hitoshi

  First Department of Medicine, Niigata University School of Medicine

• Tachikawa Hitoshi

  Department Of Cardiology Niigata University School Of Medicine

• Watanabe K

  Cardiovascular Division Tsubame Rosai Hospital

• Watanabe Kenichi

  Division Of Cardiology Tsubame Rosai Hospital

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Kodama Makoto

  First Dep. Of Medicine Graduate School Of Medical And Dental Sciences Niigata Univ.

• Watanabe Kenichi

  燕労災病院

• Tachikawa Hitoshi

  First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

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