Noninvasive myocardial endothelial intervention in the persistence of coronary stenosis: a concept of myocardial endothelial nitric oxide activator through heart failure research on clinical demand
スポンサーリンク
概要
- 論文の詳細を見る
Protection of ischemic myocardium has been attempted by a variety of pharmaceutical and non-pharmaceutical methods. When the coronary intervention is not indicated by some reasons in patients with ischemic heart failure, medical treatments are expected to offer cardioprotection against the persistence of stenotic/occlusive lesions of the epicardial coronary artery. The pharmaceuticals such as the angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, beta blocker, Ca antagonist, ATP-sensitive K channel opener and statin, or non-pharmaceutical approaches such as physical exercise, cardiac resynchronization, ventricular assist devices, and preconditioning upon ischemic insults appear to improve myocardial endothelial nitric oxide (NO) synthase (eNOS) function. Such eNOS activation contributes to amelioration of the cardiac dysfunction and remodeling induced by myocardial ischemia. Therefore, based on clinical evidence and basic research on clinical demand, we postulate a concept of 'myocardial endothelial NO activator' from the standpoint of mechanistic insights beyond the class-effects of each pharmaceutical category and each non-pharmaceutical intervention. In addition to such continuous eNOS activation for treating chronic ischemic heart failure, rapid eNOS activation in the setting of acute ischemic events upon chronic myocardial ischemia by new strategies such as postconditioning seems to be also essential for developing further effective anti-heart-failure therapies.
- 福島県立医科大学の論文
著者
-
Maruyama Yukio
Department of Cardiology, Hoshi General Hospital
-
矢尾板 裕幸
福島県立医科大学第一内科
-
小川 一英
福島県立医科大学内科学第一講座
-
YAOITA Hiroyuki
Department of Cardiology and Hematology, Fukushima Medical University
-
OGAWA Kazuei
Department of Cardiology and Hematology, Fukushima Medical University
-
Watanabe Kenichi
First Department of Internal Medicine, Fukushima Medical University
-
Watanabe Kenichi
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
-
小川 一英
福島県立医科大学 第1内科
-
Maruyama Yukio
Department Of Cardiology And Hematology Fukushima Medical University
-
Maruyama Yukio
福島県立医科大学 第一内科
-
Watanabe Kenichi
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac
-
Yaoita Hiroyuki
Department Of Cardiology And Hematology Fukushima Medical University
-
Ogawa Kazuhide
First Department of Internal Medicine
-
Maruyama Y
Department Of Cardiology And Hematology Fukushima Medical University
-
Ogawa Kazuei
Department Of Cardiology And Hematology Fukushima Medical University
-
Ogawa Kazuei
Internal Medicine Fukushima Medical University School Of Medicine
-
Ogawa Kazuhide
First Department Of Internal Medicine Fukushima Medical College
-
Maruyama Y
東北大学 第1内科
-
Ogawa Kazuei
The First Department Of Internal Medicine Fukushima Medical University
-
Watanabe Kenichi
First Department Of Internal Medicine Fukushima Medical University
-
小川 一英
Department of Cardiology and Hematology, Fukushima Medical University School of Medicine
関連論文
- PJ-127 Initial Result of Retrograde Approach for Chronic Total Occlusion (CTO) Lesions of Coronary Artery Disease(PJ021,Coronary Revascularization, PCI (Complex Lesions) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
- 心臓核医学検査ガイドライン(循環器病の診断と治療に関するガイドライン(2003-2004年度合同研究班報告))
- ダイジェスト版 : 心臓核医学検査ガイドライン
- 心臓核医学検査ガイドライン
- PJ-127 Initial Result of Retrograde Approach for Chronic Total Occlusion (CTO) Lesions of Coronary Artery Disease(PJ021,Coronary Revascularization, PCI (Complex Lesions) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
- 34)修正大血管転位症術後のIncisinal ATに対してCARTOしたにアブレーションを施行した一例(第144回日本循環器学会東北地方会)
- 34)心筋梗塞様の心筋シンチ所見を呈した左室緻密化障害の2例(第143回日本循環器学会東北地方会)
- 29)心筋炎を合併した心ファブリー病の1例(第143回日本循環器学会東北地方会)
- 2)冠動脈疾患・睡眠時無呼吸症候群を合併した起肥満メタボリックシンドロームの二例(第143回日本循環器学会東北地方会)
- 1)巨大な心室瘤を認めた心サルコイドーシスの一例(第142回日本循環器学会東北地方会)
- 29)洞調律下にCARTOsystemを用い心室頻拍のアブレーションに成功した拡張型心筋症の一例(第141回日本循環器学会東北地方会)
- 発熱とリンパ節腫脹後に特異な左房内血栓を形成し, 手術により摘出し得た1例(第139回日本循環器学会東北地方会)
- 副交感神経緊張時に頻発する右心耳起源心房頻拍症に対しカテーテルアブレーションを施行した一例(第139回日本循環器学会東北地方会)
- 24) 多発性塞栓症を併発し,手術時期の決定に苦慮した感染性心内膜炎の一例(第138回日本循環器学会東北地方会)
- 32)アミオダロン服用中に肝臓CT値の高値を来した1例(第141回日本循環器学会東北地方会)
- BOOPを併発した拡張型心筋症にステロイドが有効であった1例(第140回日本循環器学会東北地方会)
- プロスタグランジン_12持続静注療法を施行し,肺移植待機中に死亡した原発性肺高血圧症の一例(日本循環器学会東北地方会第135回学術集会)
- 24)ボセンタン内服とエポプロステノール持続静注療法の併用で退院可能となった強皮症続発肺高血圧症の一例(第144回日本循環器学会東北地方会)
- ミトコンドリア3243点変異に伴う心筋症の一例(第136回日本循環器学会東北地方会)
- 14) ICD植え込み後に自家末梢血幹細胞移植を施行し,心筋拡張障害の改善を確認し得た心アミロイドーシスの一例(第145回日本循環器学会東北地方会)
- 26)女性高脂血症患者に対する脂質低下療法による心筋,末梢微小循環障害の改善効果(第144回日本循環器学会東北地方会)
- Participation of mast cells in angiogenesis in the border zone of myocardial infarction in rats
- PJ-127 Initial Result of Retrograde Approach for Chronic Total Occlusion (CTO) Lesions of Coronary Artery Disease(PJ021,Coronary Revascularization, PCI (Complex Lesions) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
- Attenuation of Cardioprotective Effect by Postconditioning in Coronary Stenosed Rat Heart and Its Restoration by Carvedilol
- Attenuation of Diastolic Heart Failure and Life-Threatening Ventricular Tachyarrhythmia After Peripheral Blood Stem Cell Transplantation Combined With Cardioverter-Defibrillator Implantation in Myeloma-Associated Cardiac Amyloidosis
- Prediction of Remote Left Ventricular Volumes and Functions After Acute Myocardial Infarction With Successful Coronary Intervention
- 36) Fallot四徴症術後遠隔期に頻拍症を生じた2症例(第138回日本循環器学会東北地方会)
- 静注血栓溶解療法にて救命し得た,広範な左主幹部急性心筋梗塞の一例(日本循環器学会東北地方会第135回学術集会)
- 静脈血栓塞栓症に対する診断と治療経験
- 心筋虚血に対する自己骨髄/末梢血幹細胞移植による血管新生療法の経験(日本循環器学会東北地方会第135回学術集会)
- 大動脈2尖弁, 上行大動脈拡張症, 左鎖骨下動脈分岐異常を合併した Turner 症候群の一例(第139回日本循環器学会東北地方会)
- 冠動脈内ステント留置後の薬物による再狭窄予防多施設共同研究(日本循環器学会東北地方会第135回学術集会)
- 安静時^Tl心筋シンチグラフィによる心筋viability評価の検討
- 55) 心室性頻拍に対する臨床的検討(第1報) : ホルター心電図とlate potentialの比較 : 日本循環器学会第91回東北地方会
- 29)エンドセリン受容体拮抗薬によりエポプロステノール持続静注療法から離脱しえた特発性肺動脈高血圧症の一例(第142回日本循環器学会東北地方会)
- P433 器質的冠動脈狭窄のない運動負荷時ST下降例における運動負荷タリウム心筋SPECT所見と冠微小循環機能
- NONINVASIVE MYOCARDIAL ENDOTHELIAL INTERVENTION IN THE PERSISTENCE OF CORONARY STENOSIS : A CONCEPT OF MYOCARDIAL ENDOTHELIAL NITRIC OXIDE ACTIVATOR THROUGH HEART FAILURE RESEARCH ON CLINICAL DEMAND
- 非心筋細胞の培養上清による心筋虚血・再灌流障害軽減効果(日本循環器学会東北地方会第135回学術集会)
- P247 低酸素,再酸素化刺激における心筋細胞死の検討
- Unexpected Worsening of Mitral Regurgitation After Surgical Closure of Atrial Septal Defect
- RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits
- 64) 心室細動をきたした劇症型心筋炎の救命にPCPSが有効であった一例
- 44)心房中隔欠損症術後に僧帽弁逆流が増悪した僧帽弁形成不全の1例(第141回日本循環器学会東北地方会)
- 32) アセチルコリンにより冠微小血管由来の血流減少を呈した可逆性左室壁運動障害の一例
- 高血圧及びインスリン依存性糖尿病ラットにおける心拡張能,収縮能障害の検討(第136回日本循環器学会東北地方会)
- 20) 虚血性心不全におけるL-arginineの抗心不全効果の実験的検討
- 5) 左心室内血栓症と深部静脈血栓症をきたした若年者心不全の1例
- 高脂血症患者の心筋内微小循環障害の評価
- 23)急性心筋梗塞を発症した巨大右冠動脈瘤の一例(第142回日本循環器学会東北地方会)
- 6)MD-CTが診断に有用であった,バルサルバ洞動脈瘤を来した感染性心内膜炎の一例(第142回日本循環器学会東北地方会)
- ラット等の小動物における新しい心機能評価指標 : 組織 strain 法の妥当性についての検討(第140回日本循環器学会東北地方会)
- DCMにおける安静時心筋内血流速度は遠隔期左室収縮能と関連する
- DCMにおける安静時心筋内血流速度は遠隔期左室収縮能と関連する
- 0126 慢性虚血心における心室リモデリング及び冠循環障害への作用効果はβ遮断薬により異なる
- 34) 異なる心筋虚血状態におけるカルベジロール及びプロプラノロールの左室リモデリング抑制効果の比較検討
- 0137 異なる心筋虚血状態におけるカルベジロール及びプロプラノロールの左室リモデリング抑制効果の比較検討
- 0135 冠狭窄によるラット慢性虚血心の左室リモデリングに対するアンジオテンシン変換酵素阻害薬とアンジオテンシンII受容体拮抗薬の効果
- 0486 冠狭窄ラットにおける心室リモデリングの検討
- P330 ラット生体肺虚血再灌流におけるスーパーオキサイドの産生動態
- PE-538 Human Autologous Bone Marrow-derived Cell Transplantation(BMCT) Combined with Off-pump Coronary Bypass Surgery(OPCAB), Assessment of Feasibility, Mechanisms and Histopathological Findings(Regeneration (angionenesis/myocardial regeneration)-4 (M) PE
- Difference in Early Effects of Statin Therapy on Coronary and Forearm Flow Reserve in Postmenopausal Hypercholesterolemic Women
- PJ-250 Difference in Short-term Effects of Statin Therapy on Coronary and Forearm Flow Reserve in Postmenopausal Hypercholesterolemic Japanese Women(Echo/Doppler-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-170 Assessment of Microvascular Dysfunction by Myocardial Blood Velocity in Patients with Hyperlipoproteinemia(Echo / Doppler-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-275 Improvement of Microvascural Dysfunction by Cholesterol-lowering Therapy in Patients with Hypercholesterolemia is Different between Forearm and Coronary Arterial Beds(Echo/Doppler-5 (I) OJ46,Oral Presentation (Japanese),The 70th Anniversary Annual
- OJ-171 Myocardial Flow Velocity at Rest Predicts Improvement of Systolic Function in Patients with Dilated Cardiomyopathy(Echo/Doppler-4 (I) OJ29,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
- A Positive Correlation of the Grade of Endothelial Dysfunction between Forearm and Coronary Arterial Beds in Patients with Hyperlipidemia (Peripheral Circulation/Vascular Disease 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Myocardial Flow Velocity at Rest Predicts Functional Prognosis of Dilated Cardiomyopathy(Echo/Doppler 16 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-188 The Detection of Microheterogeneity in Myocardial Perfusion by Myocardial Contrast Echocardiography(Echo/Doppler 8 (I) : PE32)(Poster Session (English))
- Vasoconstrictive Response in the Vascular Beds of the Non-Exercising Forearm During Leg Exercise in Patients With Mild Chronic Heart Failure
- 3)当科におけるCypher stentの使用成績(第141回日本循環器学会東北地方会)
- 心室細動をきたした僧帽弁逸脱症候群の一例(第136回日本循環器学会東北地方会)
- Heme Oxygenase-1 Deficiency Increases the Generations of Reactive Oxygen Species and the Expression of Plasminogen Activator Inhibitor-1
- Carbon Monoxide from Heme Oxygenase-1 Scavenges Reactive Oxygen Species Generated by Oxidized LDL in Macrophages through P38 MAP Kinase Pathway
- 85)拡張型心筋症の4剖検例 : 日本循環器学会第88回東北地方会
- 56)糖尿病性動脈硬化巣のAdvanced Glycation End Products (AGEs)とMatrix Metalloproteinases (MMPs)(第141回日本循環器学会東北地方会)
- A New Rat Model of Diabetic Cardiomyopathy and a New Therapeutic Strategy with a Fibrate (Cardiac Hypertrophy/Cardiomyopathy 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Role of Advanced Glycation End Products (AGEs) in Increased Matrix Metalloproteinases (MMPs) Expression in Patients with Diabetes Mellitus (DM)(Diabetes/Obesity 9 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-196 Assessment of regional cardiac function of chronic ischemic myocardium in rats by strain-rate imaging(Echo/Doppler 9 (I) : PE33)(Poster Session (English))
- OJ-039 Correlation between Atherosclerotic Plaque Instability and Matrix Metalloproteinase(MMPs) Expression in Autopsy Cases of Diabetes Mellitus(DM)(Diabetes/Obesity 1 (H) : OJ5)(Oral Presentation (Japanese))
- 14) 冠動脈疾患患者静脈血におけるNOxとフリーラジカルの関連(日本循環器学会 第131回東北地方会)
- Transient Improvement of Left Ventricular Function After Peripheral Blood Stem Cell Transplantation in a Patient With Myelodysplastic Syndrome and Dilated Cardiomyopathy
- 6)再灌流後の急性心筋梗塞における遠隔期左室容積と左室機能の予測因子 : 心筋シンチグラフィーによる検討(第143回日本循環器学会東北地方会)
- OJ-077 Detection of Myocardial Ischemia by Diastolic Myocardial Velocity Exercise Stress Echocardiography : Comparison with Exercise Stress Technetium-99m Myocardial Perfusion Scintigraphy(Echo / Doppler-04, The 71st Annual Scientific Meeting of the Japan
- PJ-788 Scintigraphic Predictors of Remote Left Ventricular Volumes and Function in Acute Myocardial Infarction with Successful Reperfusion(Nuclear cardiology-9 (H) PJ138,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- Low Serum Ferritin Levels as a Clue to Colonic Cancer Detection in Two Patients with Coronary Artery Disease : A Case Report
- 19) 不安定狭心症にてIABP使用中胸部大動脈の自然解離を生じた1例
- The Long-Term Survival Rates of Patients After Repair of Abdominal Aortic Aneurysms
- Advantage of vein grafts for anomalous origin of a right coronary artery
- PE-068 Attenuation of Cardioprotective Effect by Postconditioning in Coronary Stenosed Rat Heart and its Reversal by Carvedilol(Myocardial ischemia/reperfusion, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-270 Hypercholesterolemia Attenuates Cardioprotective Effect of Postconditioning in Association with Endothelial Nitric Oxide Dysfunction in Rat Acute Myocardial Infarction(Myocardial ischemia-reperfusion, basic/clinical-4 (IHD) PE45,Poster Session (Eng
- OE-084 Cardioprotective Effect of Postconditioning is Attenuated through Endothelial Nitric Oxide Dysfunction in Rat Chronic Ischemic Myocardium due to Coronary Stenosis(Acute myocardial infarction, basic-1 (IHD) OE14,Oral Presentation (English),The 70th
- OE-031 Characteristics of Hospitalized Heart Failure Patients Who Have Also Chronic Kidney Disease(Heart failure, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 37) 経皮的冠動脈形成術後の無症候性再狭窄の検討 : 運動負荷タリウム心筋シンチの経時的比較
- 0016 経時的運動負荷タリウム心筋シンチは経皮的冠動脈形成術の無症候性再狭窄を予測しうるか
- 22) ラット慢性冠狭窄心における虚血プレコンディショニング効果の変化(第138回日本循環器学会東北地方会)
- Risk factors for encapsulating peritoneal sclerosis in patients who have experienced peritoneal dialysis treatment
- Bilirubin and Carbon Monoxide, Heme Oxygenase Products, Executes Different Protection Strategies for Vascular Endothelium against Oxidative Stresses(Clinical Importance of Endothelial Function Testing as a Marker of Cardiovascular Disease, The 69th Annual
- DUPLICATION OF THE TRICUSPID VALVE WITH EBSTEIN ANOMALY
- Mycotic Abdominal Aortic Aneurysm Associated with Myelodysplastic Syndrome (MDS) : Report of a Case
- Noninvasive myocardial endothelial intervention in the persistence of coronary stenosis: a concept of myocardial endothelial nitric oxide activator through heart failure research on clinical demand