Nifekalant Hydrochloride Suppresses Severe Electrical Storm in Patients With Malignant Ventricular Tachyarrhythmias

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概要

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• Background Some patients with an implantable cardioverter-defibrillator (ICD) suffer from burst of inappropriate multiple discharges (severe electrical storm), and because the current therapeutic options are limited, the effect of nifekalant hydrochloride, a new class III drug, on severe electrical storm was investigated in the present study. Methods and Results Ninety-one consecutive patients treated with ICD were included in the study (M 70; mean age 58 years; left ventricular ejection fraction 45±15%). Severe electrical storm was defined as more than 10 ICD discharges within 1h. During a mean follow-up period of 30±13 months, 41/91 (45%) patients had appropriate ICD therapy for arrhythmias and severe electrical storm occurred in 11 of them (12%) at 20±18 months after ICD implantation. The mean number of ICD discharges/h during severe electrical storm was 18±12. In 4 of 10 patients, severe electrical storm was successfully suppressed by a combination of deep sedation and β-blocking agent; 6 other patients were refractory to this treatment, but severe electrical storm was successfully suppressed by intravenous administration of nifekalant hydrochloride with no adverse effects. Conclusions Nifekalant hydrochloride is an effective and safe treatment for severe electrical storm.

• 社団法人日本循環器学会の論文
• 2005-11-20

著者

• Aizawa Yoshifusa

  First Department of Internal Medicine, Niigata University School of Medicine

• Furushima Hiroshi

  First Department of Internal Medicine, Niigata University School of Medicine

• Furushima Hiroshi

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Furushima Hiroshi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Furushima Hiroshi

  Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical An

• Chinushi Masaomi

  Niigata School Of Health Science

• Chinushi Masaomi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Komura Satoru

  First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine

• Tanabe Yasutaka

  First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine

• Washizuka Takashi

  First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine

• Tamura Yusuke

  1st. Department Of Internal Medicine Niigata University School Of Medicine

• Tanabe Yasuhiko

  Saiseikai Niigata Daini Hospital

• Tamura Yusuke

  新潟大学 医歯学総合研究科循環器学分野

• HOSAKA Yukio

  First Department of Internal Medicine, Niigata University School of Medicine

• Hosaka Yukio

  First Department Of Internal Medicine Niigata University School Of Medicine

• Washizuka Takashi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Sugiura Hirotaka

  The Division of Cardiology Niigata University Graduate School of Medical and Dental Sciences

• Hirono Takashi

  The Division of Cardiology Niigata University Graduate School of Medical and Dental Sciences

• Honda Yasuyuki

  Sado General Hospital

• Komura Satoru

  新潟大学 医歯学総合研究科循環器学

• Komura S

  1st Department Of Internal Medicine Niigata University School Of Medicine

• Watanabe Hiroshi

  First Department of Internal Medicine Niigata University Hospital

• Sugiura Hirotaka

  First Department of Internal Medicine Niigata University Hospital

• Hirono Takashi

  First Department of Internal Medicine Niigata University Hospital

• Hosaka Yukio

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science

• Tanabe Yasuhiko

  Department Of Internal Medicine Niigata Prefectural Shibata Hospital

• Washizuka Takashi

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science

• Tanabe Yasutaka

  Department Of Cardiology Niigata City General Hospital

• Watanabe Hiroshi

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science

• Tanabe Yasutaka

  First Department Of Internal Medicine Niigata University School Of Medicine

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Tanabe Yasutaka

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Chinushi Masaomi

  Department Of Clinical Pharmacology Niigata College Of Pharmacology

• WASHIZUKA Takashi

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

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