T Cell-mediated Induction of Anti-GBM Glomerulonephritis in WKY Rats
スポンサーリンク
概要
- 論文の詳細を見る
Glomerulonephritis induced in Wistar Kyoto (WKY) rats by the intravenous administration of rabbit anti-glomerular basement membrane antibody is characterized by a glomerular accumulation of T lymphocytes and monocytes/macrophages, crescent formation, and massive proteinuria. Although this model was initiated by the antibody injection, the involvement of cell-mediated immunity was also suggested since a crucial role of CD8-positive T lymphocytes was demonstrated in the induction of this model. An implication of humoral and cell-mediated immunity in this model was examined in the present study. The glomerular lesions and urinary protein excretion were deteriorated in rats preimmunized with rabbit IgG or inoculated with rabbit IgG-sensitized rat lymphocytes before the glomerular basement membrane (anti-GBM) antibody administration. In contrast, the anti-GBM glomerulonephritis was ameliorated by the passive transfer of a rat anti-rabbit IgG antibody. These observations suggested that cell-mediated immunity advanced the disease and humoral immunity suppressed it. We then examined the involvement of T cell receptor αβ on T lymphocytes by administrating a monoclonal antibody against the receptor (R73) in rats before or after the anti-GBM antibody injection. Pretreatment with the antibody markedly suppressed the glomerular lesion and proteinuria. However, the suppressive effect was minimal in rats given the antibody after the anti-GBM antibody injection. These results showed that the anti-GBM nephritis in WKY rats was mediated by T cell receptor αβ to initiate cell-mediated immunity.
- 新潟大学の論文
著者
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Yoshida Yutaka
Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sc
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Yamamoto Tadashi
Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sc
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山本 格
新潟大学付属腎研究施設構造病理学分野
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山本 格
新潟大学腎研究施設
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山本 格
新潟大学大学院医歯学総合研究科 腎研究施設構造病理学部門
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Yamamoto Tadashi
Department Of Cardiology Kouseikai Hospital
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Yaoita Eishin
Departmanets of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental
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Fujinaka Hidehiko
Institute for Clinical Research, Niigata National Hospital
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ZOU Jun
Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental S
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KOVALENKO Pavel
Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental S
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FUJINAKA Hidehiko
Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental S
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EL-SHEMI Adel
Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental S
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MATSUKI Asako
Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental S
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QU Zhenylin
Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental S
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WILSON Curtis
Department of Immunology, The Scripps Research Institute
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Fujinaka Hidehiko
Institute For Clinical Research Niigata National Hospital
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Funaki Haruko
新潟大学医学部附属腎研究施設
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El-shemi Adel
Department Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental Sci
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山本 格
新潟大学医学部附属腎研究施設
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Zou Jun
Department Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental Sci
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Zou Jun
Department Of Ophthalmology Shanghai Jiaotong University Affiliated Sixth People's Hospital
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Qu Zhenyun
Department Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental Sci
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Wilson Curtis
Department Of Immunology The Scripps Research Institute
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Yamamoto T
Dep. Of Structural Pathology Inst. Of Nephrology Graduate School Of Medical And Dental Sciences Niig
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El-shemi Adel
Department Of Physics Faculty Of Science El-minia University
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Kovalenko Pavel
Department Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental Sci
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Yutaka Yoshida
Departmanets Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental S
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Yaoita Eishin
Departmanets Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental S
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Yoshida Yutaka
Departmanets Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental S
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Matsuki Asako
Department Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental Sci
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Yoshida Yutaka
Division Of Applied Sciences Graduate School Of Engineering Muroran Institute Of Technology
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Zou Jun
Department Of Electronic Engineering Shanghai Jiao Tong University
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Yoshida Yutaka
Deparlment Of Internal Medicine School Of Medicine Kobe University
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Yoshida Yutaka
Departmanets of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University
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Yamamoto Tadashi
Departmanets of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University
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