A New Postcolumn Addition Method of the Matrix for Microbore Liquid Chromatography/Frit-Fast Atom Bombardment Mass Spectrometry
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概要
- 論文の詳細を見る
In the combination of liquid chromatography (LC)-fast atom bombardment mass spectrometry (FABMS), a new frit postcolumn addition of matrix (frit-PAM) system was designed to overcome the problems such as the diffusion of analytes and the ineffective ionization on FAB probe under the slow mobile phase flow. This system had a coaxial flow of LC effluent and FAB matrix in two separate tubes, and a frit to mix the both flows. The potential of this system was explored in the Frit-FAB LC/MS analysis of the tryptic digest of lysozyme as a test sample. This system can allow to use the mobile phases for the optimum separation in LC and the FAB matrix solution for the optimum ionization of analytes in FABMS, respectively, and can provide a high sensitivity.
- 日本質量分析学会の論文
著者
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SATO Tadashi
Department of Environmental Science, Faculty of Science, Niigata University
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MANO Nariyasu
Department of Pharmacy, Tohoku University Hospital
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Yoshida Yutaka
Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sc
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ASAKAWA Naoki
Department of Pharmaceutical Research, Tsukuba Research Laboratories, Eisai Co., Ltd.,
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Asakawa N
Eisai Co. Ltd. Ibaraki Jpn
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Asakawa N
Eisai Tsukuba Research Laboratories
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Asakawa Naoki
Analytical Chemistry And Pharmaceutical Research Division Tsukuba Research Laboratories Eisai Co. Lt
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Asakawa Naoki
Department Of Biomolecular Engineering Tokyo Institute Of Technology
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Asakawa Naoki
Preclinical Research Laboratories Eisai Co. Ltd.
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OHE Hiroshi
Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd.
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ODA Yoshiya
Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd.
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SHIKATA Yasushi
Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd.
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Yoshida Yutaka
Departmanets Of Structural Pathology Institute Of Nephrology Graduate School Of Medical And Dental S
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Mano Nariyasu
Department Of Clinical Pharmacy Tohoku University Graduate School Of Pharmaceutical Sciences
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Sato Tadashi
Department Of Environmental Science Faculty Of Science Niigata University
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Sato Tadashi
Department Of Applied Chemistry Faculty Of Science And Engineering Waseda Uiversity
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Yoshida Yutaka
Deparlment Of Internal Medicine School Of Medicine Kobe University
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SATO Tadashi
Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd.
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ASAKAWA Naoki
Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd.
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MANO Nariyasu
Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd.
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