The Relationship Between Acute Phase Serum Amyloid A (SAA) Protein Concentrations and Left Ventricular Systolic Function in Acute Myocardial Infarction Patients Treated With Primary Coronary Angioplasty
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概要
- 論文の詳細を見る
Background: Our study was planned to investigate the relationship between plasma levels of serum amyloid A protein (SAA) concentrations and the subsequent left ventricular systolic function in patients with acute myocardial infarction (AMI) treated with primary coronary angioplasty. Methods and Results: Reperfusion by primary percutaneous coronary intervention was successful in 486 consecutive AMI patients who were admitted within 12 hours of onset. Plasma SAA concentrations were evaluated 24 hours after onset. Left ventricular (LV) function was serially determined by left ventriculography performed in the acute (soon after recanalization) and chronic phases (6 months after onset). (I) There was no significant correlation between SAA concentration and acute phase left ventricular ejection fraction (LVEF) or regional wall motion (RWM). (II) The SAA concentration was significantly correlated with both highly sensitive C-reactive protein (hs-CRP) and the peak-CK value (hs-CRP: r = 0.69, P < 0.0001, peak-CK: r = 0.21, P = 0.0003). (III) SAA was significantly negatively correlated with both LVEF and RWM in the chronic phase (LVEF: r = -0.42, P = 0.001; RWM: r = -0.41, P = 0.007). (IV) The plasma level of SAA also showed a significant negative correlation with the differences in LVEF between the 2 stages (delta-LVEF) (r = -0.43, P = 0.02). Conclusion: In the setting of AMI, plasma SAA concentrations may be closely related to subsequent left-ventricular systolic dysfunction.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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Nakashima Hiroshi
Department Of Cardiology Nagasaki Citizens Hospital
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Yamamoto Tadashi
Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sc
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Suzuki Shin
Department of Cardiology, Sakakibara Heart Institute
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Katayama Toshiro
Department of Cardiology, Nagasaki Kouseikai Hospital
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Iwasaki Yoshihiro
Department of Cardiology, Nagasaki Kouseikai Hospital
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Iwasaki Yoshihiro
Department Of Cardiology Kouseikai Hospital
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Katayama Toshiro
Department Of Cardiology Kouseikai Hospital
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Katayama Toshiro
光晴会病院 循環器内科
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Yano Katsusuke
Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of B
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Honda Yukiharu
Department of Cardiology, Nagasaki Citizens Hospital
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Honda Yukiharu
Department Of Cardiology Nagasaki Citizens Hospital
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Suzuki Shin
Department Of Cardiology Nagasaki Citizens Hospital
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Yano Katsusuke
Department Of Cardiology Nagasaki University Hospital
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Nakashima Hiroshi
Department Of Biology Faculty Of Science Okayama University
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Yamamoto Tadashi
Departmanets of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University
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Yano Katsusuke
Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University
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