<Review>Physical Exercise and Extracellular Superoxide Dismutase:Antiatherogenic Effects
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概要
- 論文の詳細を見る
OHNO, H., KIZAKI, T., SUZUKI, K., HITOMI, Y., WATANABE, A., OOKAWARA, T., SUZUKI, K., HAGA, S., SAITO, D., RADAK, Z. and Li Li JI, Physical Exercise and Extracellular Superoxide Dismutase:Antiatherogenic Effects. Adv. Exerc. Sports Physiol., Vol.9, No.2 pp45-53, 2003. It has been well known that strenuous of endurance exercise causes oxidative stress to the body due to the increased oxygen consumption and the enhanced generation of reactive oxygen species(ROS), thus potentially damaging the cell membrance and organelles. Superoxide dismutanse (SOD), which serves to convent super anion (O2-) to oxygen (O2) and hydrogen peroxide (H2O2), is one of the most important antioxidant enzymes. Three types of SOD isoenzymes, i.e., Cu,Zu-SOD, Mn-SOD, and extrancellular (EC) SOD, have been identified in mammals. Compared to Cu,Zn-SOD and Mn-SOD, there are much fewer available reports on physical exercise and EC-SOD. EC-SOD is a secretory glycoprotein with an affinity for heparin-loke substances, which is located in extracellular fluids, including plasma dna the extracellular matrix. In the vessel wall, a major isoform of SOD is the EC-SOD. Because of its location, EC-SOD has been hailed as the principal regulator of endotheliun-derived nitric oxide (NO) bioactivity with the antiatherogenic and vasodilation effects. Thus, this review will discuss the characteristics of EC-SOD and the role of EC-SOD in physical exercise, especially focussing on its antiatherogenic effects.
- 日本運動生理学会の論文
著者
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OHNO Hideki
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
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KIZAKI Takako
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
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HAGA Shukoh
Institute of Health and Sport Sciences, University of Tsukuba
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Suzuki Kenji
Department Of Cardiology Kyoto Second Red Cross Hospital
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KIZAKI Takako
Kyorin University
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HAGA Shukoh
Nihonbashigakkan University
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OHNO Hideki
Kyorin University
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Hitomi Yoshiaki
Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine
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Hitomi Yoshiaki
Department Of Environmental And Preventive Medicine Graduate School Of Medical Science Kanazawa Univ
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Haga Shukoh
Institute Of Health & Sports Sciences University Of Tsukuba
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Suzuki K
Laboratory Of Molecular Medicinal Sciences Department Of Bioscience And Bioinformatics College Of In
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Suzuki Kenji
Department Of Applied Physics Osaka University
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SAITOH Daizoh
Department of Traumatology and Critical Care Medicine, National Defense Medical College
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Ji Li
Department Of Kinesiology And Interdisciplinary Graduate Program Of Nutritional Science University O
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WATANABE Sumiko
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
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OOKAWARA Tomomi
Department of Biochemistry, Hyogo University of Medicine
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SUZUKI Keiichiro
Department of Biochemistry, Hyogo University of Medicine
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RADAK Zsolt
Laboratory of Exercise and Physiology, School of Sport Sciences, Semmelweis University-Buda-pest
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Ohno Hideki
Department Of Hygiene National Defense Medical College
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RADAK Zsolt
Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University
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Haga Shukoh
Institute Of Health An Sport Sciences University Of Tsukuba
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Suzuki Keiichiro
Department Of Biochemistry Hyogo College Of Medicine
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Radak Zsolt
Laboratory Of Exercise And Physiology School Of Sport Sciences Semmelweis University-buda-pest
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Saitoh Daizoh
Department Of Traumatology And Critical Care Medicine National Defense Medical College
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Kinugasa Takashi
Kyorin University
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Ookawara Tomomi
Department Of Biochemistry Hyogo University Of Medicine
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Ohno Hideki
Department Of Gastroenterology Graduate School Of Medicine University Of Tokyo
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Watanabe Sumiko
Department Of Molecular Predictive Medicine And Sport Medicine Kyorin University School Of Medicine
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Watanabe Sumiko
Department Of Health Effects Research National Institute Of Industrial Health:department Of Hygiene
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Kizaki Takako
Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine
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Ookawara Tomomi
Department Of Biochemistry Hyogo College Of Medicine
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Suzuki Kenji
Department Of Anesthesia Kitakami Saiseikai Hospital
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Hitomi Yoshiaki
Department Of Environmental And Preventive Medicine Faculty Of Medicine Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University
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Haga Shoukoh
Institute of Health and Sport Sciences, University of Tsukuba
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OHNO Hideki
Department of Gastroenterology and Cancer Gene Regulation, Kanazawa University Graduate School of Medical Sciences
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Watanabe Sumiko
Department of Chemistry, Yokohama City University
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