Antioxidative Effects of a New Lychee Fruit-Derived Polyphenol Mixture, Oligonol, Converted into a Low-Molecular Form in Adipocytes
スポンサーリンク
概要
- 論文の詳細を見る
In this study we investigated the antioxidative effects of Oligonol (Amino Up Chemical Co., Ltd., Sapporo, Japan), a new polyphenol, in adipocytes. The levels of reactive oxygen species (ROS) and the expression of adipokine genes decreased in HW mouse white adipocytes upon treatment with Oligonol as compared to control cells. The transcriptional activity of nuclear factor-kappaB (NF-κB) and the activation of extracellular signal-regulated kinase (ERK) 1/2 were also down-regulated by Oligonol. In addition, when C57BL/6J mice were fed a high fat diet (HFD) for 5 weeks, the levels of epididymal white adipose tissue (WAT) mass and lipid peroxidation in WAT both increased, but Oligonol intake clearly inhibited such HFD-induced increases. Furthermore, dysregulated expression of genes for adipokines in WAT of mice fed solely a HFD was attenuated by Oligonol intake. These results suggest that Oligonol has antioxidative effects and that it attenuates HFD-induced dysregulated expression of genes for adipokines in adipocytes.
- 社団法人 日本農芸化学会の論文
- 2008-02-23
著者
-
OHNO Hideki
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
-
KIZAKI Takako
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
-
NAKANO Norihiko
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
-
SAKURAI Takuya
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
-
KIZAKI Takako
Kyorin University
-
HAGA Shukoh
Nihonbashigakkan University
-
IZAWA Tetsuya
Doshisha University
-
OHNO Hideki
Kyorin University
-
Fujii Hajime
Amino Up Chemical Co., Ltd.
-
Sakurai Tomonobu
Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine
-
Sakurai Takuya
Department Of Organic And Polymeric Materials Graduate School Of Science And Engineering Tokyo Insti
-
Fujii Hajime
Amino Up Chemical Co. Ltd
-
Nakano Norihiko
Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine
-
Nakano Norihiko
Department Of Biochemistry Room B-1 Osaka University Medical School
-
Ohno Hideki
Department Of Hygiene National Defense Medical College
-
HAGA Shukoh
Department of Synthetic Business Adoministration, Faculty of Liberal Arts, Nihonbashigakkan Universi
-
NISHIOKA Hiroshi
Amino Up Chemical Co., Ltd.
-
RADAK Zsolt
Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University
-
IZAWA Tetsuya
Health Promotion Science Group, Graduate School of Human Health Science, Tokyo Metropolitan Universi
-
Haga Shukoh
Institute Of Health An Sport Sciences University Of Tsukuba
-
Izawa Tetsuya
Department Of Kinesiology Tokyo Metropolitan University
-
Radak Zsolt
Laboratory Of Exercise And Physiology School Of Sport Sciences Semmelweis University-buda-pest
-
Kinugasa Takashi
Kyorin University
-
Iiyama Takeshi
Doshisha University
-
Nishioka Hiroshi
Amino Up Chemical Co. Ltd.
-
Radak Zsolt
Institute Of Sport Science Faculty Of Physical Education And Sport Science Semmelweis University
-
Ohno Hideki
Department Of Gastroenterology Graduate School Of Medicine University Of Tokyo
-
Kizaki Takako
Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine
-
Sakurai Tomonobu
Department Of Kinesiology Graduate School Of Science Tokyo Metropolitan University
-
Sakurai Takuya
Department of Electrical and Electronic Engineering, Faculty of Engineering, Shinshu University, 4-17-1 Wakasato, Nagano 380-8553, Japan
-
OHNO Hideki
Department of Gastroenterology and Cancer Gene Regulation, Kanazawa University Graduate School of Medical Sciences
関連論文
- Is Angiotensin I-Converting Enzyme I/D Polymorphism Associated with Endurance Performance and/or High Altitude Adaptation ?
- Supplementation of Antioxidants Prevents Oxidative Stress during A Deep Saturation Dive
- 2B-O-1 The mechanisms underlying prolonged exercise training : induced alterations in levels of adipose triglyceride lipase (ATGL) in rat primary adipocytes(The Proceedings of the 18th Annual Meetings of Japan Society Exercise and Sports Physiology Jury 3
- 1A-20 Effects of tumor necrosis factor-α and nitric oxide on several genes in rat adipocytes(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- Differential Effects of Buckwheat and Kudingcha Extract on Neuronal Damage in Cultured Hippocampal Neurons and Spatial Memory Impairment Induced by Scopolamine in an Eight-Arm Radial Maze
- Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated With Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia
- Exercise Training Enhances Tumor Necrosis Factor-α-Induced Expressions of Anti-Apoptotic Genes without Alterations in Caspase-3 Activity in Rat Epididymal Adipocytes
- Effects of Buckwheat in a Renal Ischemia-Reperfusion Model
- Protection by buckwheat polyphenols of cell death induced by glutamate and kainate in cultured hippocampal neurons
- Primary biliary cirrhosis associated with type A gastritis and chronic thyroiditis
- Purification and Characterization of a Novel Vascular Endothelial Cell Growth Inhibitor Secreted by Macrophage-Like U-937 Cells
- Effect of Eccentric Exercise on Neutrophil Function in Human Plasma
- Physical Exercise and Extracellular Superoxide Dismutase:Antiatherogenic Effects
- Protrein Carbonyl Content Roughly Reflects the Unsaturation of Lipids in Muscle but Not in Other Tissues of Stroke-Prone Spontaneously Hypertensive Strain (SHRSP) Rats Fed Different Fats and Oils
- NTAKα and β Isoforms Stimulate Breast Tumor Cell Growth by Means of Different Receptor Combinations
- A Novel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4^1
- Changes in Nitric Oxide and Inducible Nitric Oxide Synthase Following Stretch-Induced Injury to the Tibialis Anterior Muscle of Rabbit
- Effect of Different Intensity and Duration of Exercise with the Same Total Oxygen Uptake on Lipid Peroxidation and Antioxidant Enzyme Levels in Human Plasma
- 2-P-34 The possible mechanisms underlying acute exercise-induced alterations in lipolysis in rat primary adipocytes(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo))
- 1-O-12 Exercise training suppresses adipogenesis of adipose tissue-derived stem cells(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo))
- Swimming Training Prevents Induction of Suppressor Macrophages in Mice during Acute Exposure to Cold
- The Supplementation of Oligonol, the New Lychee Fruit-derived Polyphenol Converting into a Low-molecular Form, Has a Positive Effect on Fatigue during Regular Track-and-field Training in Young Athletes
- Antioxidative Effects of a New Lychee Fruit-Derived Polyphenol Mixture, Oligonol, Converted into a Low-Molecular Form in Adipocytes
- 4. Oxidative stress in rat white adipose tissue is decreased by exercise training(The Proceedings of the 15th Annual Meetings of Japan Society of Exercise and Sports Physiology July 26-27, (Hirosaki))
- Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy
- Gliclazide Inhibits Proliferation but Stimulates Differentiation of White and Brown Adipocytes
- 1A-10 Down-regulation of β_2-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulation(Immunology and Endocrinology, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and
- 1A-19 Effect of acute exercise on the expressions of Bax and BCL gene in rat adipocytes(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- 1B-03 Effect of exercise training on tumor necrosis factor-α-induced expressions of lipogenic genes in rat adipocytes(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- 1B-02 Acute exercise induces alteration in β-adrenergic receptor-cAMP signal transduction system via ubiquitin-pro-teasome proteolysis pathway in rat adipocytes(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise
- 1D08 The effect of exercise training and nitric oxide on the glucose-stimulated insulin secretion
- 3P14:The effect of exercise-training on the generation of nitric oxide in pancreatic islet of Langerhans
- 3P11:Effect of single bout exercise on adipocyte lipolysis(II)
- 2B-04 Temporal change of PGC-1α protein expression and oxidative capacity to endurance exercise in mouse skeletal muscles(Muscular Function, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo)
- Effects of Intensity and Duration of Endurance Exercise on Skeletal Muscle Fiber Type Transition in Mice
- The experimental system to analyze mRNA expression profiles between slow and fast muscle fibers
- We have two strategies to attain healthy aging
- Effect of Hyperventilation During Resistance Exercise on Hormonal Response in Humans
- Hematological Responses in Juveniles after Training at Moderate Altitude
- Induction of MIC1P1 mRNA in rat skeletal muscle indicates the activation of the calcineurin signaling pathway during exercise
- 2Q05 Changes in the activity-level of the cerebral cortex-the function of concentration maintenance (TAF) and influence of the exercise in the elderly
- 1Q07 Effect on blood adipose tissue and MDA-LDL with combined exercise training in middle-aged and older persons
- 2P29 Effects of Exercise Intervention on Physical Fitness and Health for Physically Independent Elderly : A Randomized Controlled Trial
- 1P14 Effects on muscle oxygenation of exercise program in older persons
- 1C04 Contribution of calcineurie pathway to overload-induced skeletal muscle fiber tpe alteration
- 1C01 Nobel method for the identification of oxidative fibers in skeletal muscle
- 3P17:Effects of endurance exercise intensity and duration on skeletal muscle fiber type in mice
- 2ME:Exercise Training and Immune Function
- Physical Exercise and Uncoupling Protein Family
- 1AD4 Effect of MAF on mitochondrial energy metabolism in C2C12 cultured myotubes(The Proceeding of the 14th Annual Meeting of Japan Society of Exercise and Sports Physiology July 29-30, (Hiroshima))
- Quantitative Contribution of Oxidative Metabolism in the Human Calf During Supramaximal Plantar Flexion Exercise
- 1D09 Effect of an acute exercise on the β-adrenergic receptor-adenylate cyclase system in rat adipocytes
- Morphological Evolution during Isothermal Crystallization Observed in a Crystalline-Crystalline Diblock Copolymer
- (E61011) Effects of inactivity on Aortic Response in rat.
- Disposition of protein-bound 3-nitrotyrosine in rat plasma analysed by a novel protocol for HPLC-ECD
- Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells
- The Synergistic Effect of Dietary Calcium Restriction and Exhaustive Exercise on the Antioxioxidant Enzyme System in Rat Heart
- O-9 Effect of hyperventilation during resistance exercise on muscle oxygenation and hormonal response in humans(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- Cardiac Output and Stroke Volume at Anaerobic Threshold During Walking Exercise in Healthy Aged Subjects
- 3P23:Effects of a community-based exercise program on the physical function and daily functional capacity of older persons of varying fitness levels
- 1P27:Effect of leg muscular strength and walking ability on health promotion exercise in elderly women
- 2E2:Effects of detraining and inactivity on antioxidant enzymes of rat skeletal muscle
- 2D3:Relationship between skeletal muscle damage and inducible nitric oxide synthase expression after running exercise
- Reactive Oxygen Species (ROS) and Exercise : 2SB1:The Present State and Future Development of the Research for Reactive Oxygen Species (ROS) and Physical Exercise
- Analysis of Combined Full Energy Peaks of Gamma-Ray Spectra
- Up-Regulation of JAM-1 in AR42J Cells Treated with Activin A and Betacellulin and the Diabetic Regenerating Islets
- Changes in the Tissue and Plasma Superoxide Dismutase (SOD) Levels in a Burned Rat Model
- Stress- and Aging-Associated Modulation of Macrophage Functions
- 242 Effect of community-based exercise program on the physical fitness and mental health of obese older women
- 128 Exercise Tolerance Capacity on Treadmill Walking in The Older Persons
- 2C-05 Effect of mild aerobic exercise training on blood coagulability and fibrinolytic activity in middle- and old-aged obese females
- (E40911) Relationship between muscle oxygenation obtained from the arterial occlusion with maximal work intensity and aerobic capacity
- Acute or Chronic Exercise Alters Angiotensin II-Induced Contraction of Rat Aorta
- Possible Role of Nitric Oxide on Adipocyte Lipolysis in Exercise-Trained Rats
- Effects of health and physical fitness classes for older adults on cardiorespiratory fitness and functional capacity
- Oxidative Metabolism in Skeletal Muscle Measured During Supramaximal Exercise in Sprinter and Active Control Groups by Near Infrared Continuous Wave Spectroscopy
- Antioxidative Effects of a New Lychee Fruit-Derived Polyphenol Mixture, Oligonol, Converted into a Low-Molecular Form in Adipocytes
- A Phase I Study of the Safety of the Nutritional Supplement, Active Hexose Correlated Compound, AHCC, in Healthy Volunteers
- 1F3:Influence of exercise training on the insulin secretion by cathecholamines
- Significant increase in the melting temperature of poly(ε-caprolactone) blocks confined in the crystallized lamellar morphology of poly (ε-caprolactone)-block-polyethylene copolymers
- 物理環境と酸化的ストレス
- Effect of physical exercise on lipolysis in white adipocytes
- Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus
- 2-B-02 Exercise has preventive effects on cognitive impairment in senescence-accelerated mice(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima))
- Effect of exercise on HIF-1 and VEGF signaling
- Effect of physical exercise on lipolysis in white adipocytes
- Recent advances in the adaptations of adipose tissue to physical activity: Morphology and adipose tissue cellularity
- The effects of exercise on macrophage function
- Formation of the 1.014 eV Photoluminescence Cu Center in Cu-implanted Silicon Crystals and the Center’s Model
- Effects of exercise on the hexosamine biosynthetic pathway and glycosylation
- Effects of β2-agonists and exercise on β2-adrenergic receptor signaling in skeletal muscles
- Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus
- Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases
- Growth and characterization of SiC films by hot-wire chemical vapor deposition at low substrate temperature using SiF4/CH4/H-2 mixture
- O-35 Signaling in the differentiation from myoblast to brown adipocyte is stimulated by swimming exercise(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba))
- Exercise and oxidative stress in hypoxia
- 1-B-6 Exercise training attenuates obesity-induced increases in expression of fibrosis-related factors in white adipose tissue(The Proceedings of the 21st Annual Meetings of Japan Society of Exercise and Sports Physiology July 27 ・ 28, (Saitama))
- A Novel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4.
- Effects of β_2-agonists and exercise on β_2-adrenergic receptor signaling in skeletal muscles
- NTAK.ALPHA. and .BETA. Isoforms Stimulate Breast Tumor Cell Growth by Means of Different Receptor Combinations.