<Originals>Effects of Intensity and Duration of Endurance Exercise on Skeletal Muscle Fiber Type Transition in Mice

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概要

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• MIYAZAKI, M., HITOMI, Y., KIZAKI, T., OHNO, H., HAGA, S., and TAKEMASA, T., Effects of Intensity and Duration of Endurance Exercise on Skeletal Muscle Fiber Type Transition in Mice. Abv. Exerc. Sports Physiol., Vol.11, No.1 pp.15-20, 2005. Skeletal muscle is highly adaptable, capable of undergoing changes in its structural and functional priperties with physiological stimuli. There is growing evidence that endurance exercise training can promote numerous adaptations in skeletal muscle, including changes in the composition of myosin heavy chain (MHC) and in fiber oxidative capacity those are better suited for prolonged muscke activation. However, fes studies have been undertaken on skeletal muscle adaptations with endurance exercise training using mice. In this study, we investigated the effects of differntial endurance exercise training on skeletal muscle fiber type in mice. Litters of male ddy mice were randomly divided into either an exercised group or a non-exercised control group. The endurance exercise training consiseted of treadmill running sessions of differential intensities (15, 20 and 25 m'min -1) and durations (30, 60 and 90 min･day-1) for four weeks, everyday. The MHC composition and citrate synthase (CS) activity of the soleus (Sol), plantaris (Pla) and tibialis anterior (TA) muscles ere analyzed. After for weeks of training, an increase in MHCHa+d/x and decrease in MHCHb were observed in the TA muscle. CS activity also ingreased in the Pla and TA muscles. In the Sol muscle, we could not observe meaningful change in MHC composistion and CS activity. These results suggest that, in mice, endurance exercise can induce the transformation of skeletal muscle phenotype in the Pla and TA muscles from fast to intermediate profile.

• 日本運動生理学会の論文

著者

• 武政 徹

  Institute Of Health And Sport Sciences University Of Tsukuba

• OHNO Hideki

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• KIZAKI Takako

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• KIZAKI Takako

  Kyorin University

• HAGA Shukoh

  Nihonbashigakkan University

• OHNO Hideki

  Kyorin University

• Hitomi Yoshiaki

  Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine

• Hitomi Yoshiaki

  Department Of Environmental And Preventive Medicine Graduate School Of Medical Science Kanazawa Univ

• Takemasa Tohru

  Department Of Anatomy I Nippon Medical School

• Ohno Hideki

  Department Of Hygiene National Defense Medical College

• HAGA Shukoh

  Department of Synthetic Business Adoministration, Faculty of Liberal Arts, Nihonbashigakkan Universi

• MIYAZAKI Mitsunori

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Haga Shukoh

  Institute Of Health An Sport Sciences University Of Tsukuba

• Mizuno Masao

  Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Kinugasa Takashi

  Kyorin University

• Ohno Hideki

  Department Of Gastroenterology Graduate School Of Medicine University Of Tokyo

• Kizaki Takako

  Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine

• Hitomi Yoshiaki

  Department Of Environmental And Preventive Medicine Faculty Of Medicine Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University

• OHNO Hideki

  Department of Gastroenterology and Cancer Gene Regulation, Kanazawa University Graduate School of Medical Sciences

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