Antioxidative Effects of a New Lychee Fruit-Derived Polyphenol Mixture, Oligonol, Converted into a Low-Molecular Form in Adipocytes

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概要

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• In this study we investigated the antioxidative effects of Oligonol (Amino Up Chemical Co., Ltd., Sapporo, Japan), a new polyphenol, in adipocytes. The levels of reactive oxygen species (ROS) and the expression of adipokine genes decreased in HW mouse white adipocytes upon treatment with Oligonol as compared to control cells. The transcriptional activity of nuclear factor-kappaB (NF-κB) and the activation of extracellular signal-regulated kinase (ERK) 1/2 were also down-regulated by Oligonol. In addition, when C57BL/6J mice were fed a high fat diet (HFD) for 5 weeks, the levels of epididymal white adipose tissue (WAT) mass and lipid peroxidation in WAT both increased, but Oligonol intake clearly inhibited such HFD-induced increases. Furthermore, dysregulated expression of genes for adipokines in WAT of mice fed solely a HFD was attenuated by Oligonol intake. These results suggest that Oligonol has antioxidative effects and that it attenuates HFD-induced dysregulated expression of genes for adipokines in adipocytes.

• 社団法人 日本農芸化学会の論文

著者

• OHNO Hideki

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• KIZAKI Takako

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• NAKANO Norihiko

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• Fujii Hajime

  Amino Up Chemical Co., Ltd.

• Sakurai Tomonobu

  Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine

• Sakurai Takuya

  Department Of Organic And Polymeric Materials Graduate School Of Science And Engineering Tokyo Insti

• HAGA Shukoh

  Department of Synthetic Business Adoministration, Faculty of Liberal Arts, Nihonbashigakkan Universi

• NISHIOKA Hiroshi

  Amino Up Chemical Co., Ltd.

• RADAK Zsolt

  Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University

• IZAWA Tetsuya

  Health Promotion Science Group, Graduate School of Human Health Science, Tokyo Metropolitan Universi

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