<Originals>Swimming Training Prevents Induction of Suppressor Macrophages in Mice during Acute Exposure to Cold

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It has long been known that acute cold stress suppresses immune responses, and that swimming training increases tolerance to cold. The aim of the current study was to investigate whether the improved cold tolerance occasioned by swimming training prevented the suppression of immune responses as a result of acute cold stress, focusing in particular on the generation of suppressor macrophages and glucocorticoid hormones. This is because acute cold stress induces the generation of suppressor macrophages that express large numbers of receptors to the Fc portion of immunoglobulin G (MAC-1^+Fc γ RII/III^<bright> cells), leading to the suppression of splenocyte mitogenesis; moreover, the generation of MAC-1^+Fc γ RII/III^<bright> cells is partly mediated by increased glucocorticoid levels during acute cold stress. The trained mice underwent a 6-week endurance swimming training (5 times/week) in water at 30℃ for 90min. The swimming training remarkably increased brown adipose tissue mass, suggesting an improved cold tolerance. Indeed, when the swimming-trained mice were exposed to 5℃ for 3h (acute cold stress), the rectal temperature was not substantially decreased, unlike the case for control mice. The proportion of MAC-1^+Fc γ RII/III^<bright> cells in peritoneal exudate cell population from the trained mice was unaffected by the acute cold stress. The swimming training significantly attenuated the increases in serum corticosterone levels in response to acute cold stress. Taken together, the results obtained suggegst that swimming training not only improves cold tolerance but also inhibits the generation of suppressor macrophages under acute cold stress.
日本運動生理学会の論文

<Originals>Swimming Training Prevents Induction of Suppressor Macrophages in Mice during Acute Exposure to Cold

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