Stress- and Aging-Associated Modulation of Macrophage Functions

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概要

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• Effects of environmental (cold) stress and aging on cells in monocyte/macrophage lineage were investigated. We demonstrated that immune suppressive states seen in acute cold-stressed mice (8-10 weeks of age) is attributable to FcγRII^<bright> suppressor macrophages. Serum corticosterone levels were markedly increased in acute cold-stressed mice. In addition, expression of glucocorticoids (GC) receptor mRNA was observed in FcγRII^<bright> cells from these mice. The increase of FcγRII^<bright> cells in peritoneal exudate cells caused by acute cold stress was inhibited by adrenalectomy or administration of a saturating amount of the GC antagonist RU 38486 (mifepristone). On the contrary, administration of the GC agonist, dexamethasone, markedly increased the proportion of FcγRII^<bright> cells in peritoneal exudate cells of control mice. These results suggest that the generation of FcγRII^<bright> suppressor cells of monocyte/macrophage lineage by acute cold stress was mediated by action of GC through the GC receptor. We likewise found that the proportion of FcγRII^<bright> suppressor macrophages is increased in aged mice (22-24 months of age). Meanwhile, activated macrophages which function as antigen presenting cells were decreased in aged rats. Both the basal corticosterone concentrations in serum and the expression of mRNA for GC receptor in peritoneal macrophages increased significantly in aged animals, suggesting that these populational and functional changes of macrophages in aged animals were mediated, in part, by the increased basal levels of GC. This is probably being responsible for immunosenescence.

• 日本衛生学会の論文

著者

• OHNO Hideki

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• KIZAKI Takako

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• IZAWA Tetsuya

  Department of Kinesiology, Graduate School of Science, Tokyo Metropolitan University

• HAGA Shukoh

  Institute of Health and Sport Sciences, University of Tsukuba

• OH-ISHI SHUJI

  Fifth Department of Internal Medicine, Tokyo Medical University

• Suzuki Kenji

  Department Of Cardiology Kyoto Second Red Cross Hospital

• KIZAKI Takako

  Kyorin University

• HAGA Shukoh

  Nihonbashigakkan University

• IZAWA Tetsuya

  Doshisha University

• OHNO Hideki

  Kyorin University

• Haga Shukoh

  Institute Of Health & Sports Sciences University Of Tsukuba

• Ohishi Shuji

  Fifth Department Of Internal Medicine Tokyo Medical University

• Izawa Tetsuya

  Department Of Exercise And Sport Science Graduate School Of Science Tokyo Metropolitan University

• Suzuki K

  Laboratory Of Molecular Medicinal Sciences Department Of Bioscience And Bioinformatics College Of In

• Suzuki Kenji

  Department Of Applied Physics Osaka University

• SAITOH Daizoh

  Department of Traumatology and Critical Care Medicine, National Defense Medical College

• OOKAWARA Tomomi

  Department of Biochemistry, Hyogo University of Medicine

• SUZUKI Keiichiro

  Department of Biochemistry, Hyogo University of Medicine

• Ohno Hideki

  Department Of Hygiene National Defense Medical College

• Haga Shukoh

  Institute Of Health An Sport Sciences University Of Tsukuba

• Izawa Tetsuya

  Department Of Kinesiology Tokyo Metropolitan University

• Suzuki Keiichiro

  Department Of Biochemistry Hyogo College Of Medicine

• Oh-ishi Shuji

  Kasumigaura Hospital Tokyo Medical University

• Saitoh Daizoh

  Department Of Traumatology And Critical Care Medicine National Defense Medical College

• OHISHI Shuji

  5th Department of Internal Medicine, Tokyo Medical University

• Kinugasa Takashi

  Kyorin University

• Ookawara Tomomi

  Department Of Biochemistry Hyogo University Of Medicine

• Ohno Hideki

  Department Of Gastroenterology Graduate School Of Medicine University Of Tokyo

• Kizaki Takako

  Department Of Molecular Predictive Medicine And Sport Science Kyorin University School Of Medicine

• Ookawara Tomomi

  Department Of Biochemistry Hyogo College Of Medicine

• Suzuki Kenji

  Department Of Anesthesia Kitakami Saiseikai Hospital

• OHNO Hideki

  Department of Gastroenterology and Cancer Gene Regulation, Kanazawa University Graduate School of Medical Sciences

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