A Novel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4.
スポンサーリンク
概要
- 論文の詳細を見る
A novel member of the epidermal growth factor (EGF) family, the neural- and thymusderived activator for ErbB kinases (NTAK), has been purified and cloned. Five alternative spliced isoforms have been detected in the rat adrenal pheochromocytoma cell line, PC-12 cells. The rat NTAKα2a isoform exhibits 94% identity in its primary sequence with the human NTAKα isoform. In vivo, NTAK is only expressed in the brain of rat E11.5 embryos, and in the brain and thymus of adult rats. The soluble 46 kDa form binds directly to ErbB3 and B4, but not to ErbB1 or B2. NTAK, however, transactivates ErbB1 and B2 via heterodimerization with ErbB3 or B4. NTAK stimulates the differentiation of MDA-MB-453 cells and competitively inhibits the binding of [125I] neuregulin to these cells. In addition to these neuregulin-like properties, NTAK exhibits limited structural homology to neuregulins in the immunoglobulin (Ig)-like, EGF-like, and hydrophobic domains. Thus, NTAK appears to be a new member of the EGF family displaying neuregulin properties.
- 社団法人 日本生化学会の論文
著者
-
Miyagawa Junichiro
Deparment Of Inernal Medicine Osaka Universithy Medical School
-
ISHIGURO Hiroshi
Institute for Comprehensive Medical Science, Fujita Health University
-
Ichino Naohiro
Institute For Comprehensive Medical Science Fujita Health Universithy
-
Yamada Kouji
Institute For Comprehensive Medical Science Fujita Health University
-
Ishiguro Hiroshi
Institute For Comprehensive Medical Science Fujita Health University
-
HORIKAWA Michiharu
Deparments of Biochemistry Osaka University Medical School
-
NAKAGAWA Takatoshi
Deparments of Biochemistry Osaka University Medical School
-
Nakano Norihiko
Department Of Biochemistry Room B-1 Osaka University Medical School
-
Nagatsu Toshiharu
Institute For Comprehensive Medical Science Fujita Health University
-
Matsushita Natsuki
Institute For Comprehensive Medical Science Fujita Health Universithy
-
Higashiyama Shigeki
Department Of Basic Laboratory Sciences School Of Allied Health Science Osaka University Faculty Of
-
Taniguchi Naoyuki
Department Of Biochemistry Osaka University Graduate School Of Medicine
関連論文
- The genome structure and the genomic comparison of a medaka hox cluster(Symposium on Comparative and Functional Genomics of Medaka)
- Is Angiotensin I-Converting Enzyme I/D Polymorphism Associated with Endurance Performance and/or High Altitude Adaptation ?
- Overexpression of the Aldose Reductase Gene Induces Apoptosis in Pancreatic β-Cells by Causing a Redox Imbalance
- Characterization of neuron-specific huntingtin aggregates in human huntingtin knock-in mice
- Isolation and characterization of a novel member of human and mouse ADAM family, ADAM33
- Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells
- Exercise Training Enhances Tumor Necrosis Factor-α-Induced Expressions of Anti-Apoptotic Genes without Alterations in Caspase-3 Activity in Rat Epididymal Adipocytes
- The New Metalloproteinase Inhibitor Blocks Cardiac Hypertrophy Induced by both Phenylephrine and Angiotensin II
- Purification and Characterization of a Novel Vascular Endothelial Cell Growth Inhibitor Secreted by Macrophage-Like U-937 Cells
- DPE-002 Regulation of Ectodomain Shedding of Heparin Binding-Epidermal Growth Factor (HB-EGF) in Adipocytes(DPE01,Metabolic Syndrome (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- NTAKα and β Isoforms Stimulate Breast Tumor Cell Growth by Means of Different Receptor Combinations
- A Novel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4^1
- Purification and cDNA cloning of GDP-L-Fuc:N-Acetyl-β-D-Glucosaminide:α1-6 Fucosyltransferase (α1-6 FucT) from Human Gastric Cancer MKN45 Cells^1
- The Protective Role of Glutathione Peroxidase in Ppoptosis Induced by Reactive Oxygen Species^1
- Heparin-binding Epidermal Growth Factor-like Growth Factor: p91 Activation, Induction of Plasminogen Activator/Plasminogen Activator Inhibitor, and Tubular Morphogenesis in Human Microvascular Endothelial Cells
- High-Level Expression of Heat-Stable Enterotoxin (ST) Receptor with Exchange of the Signal Peptide in Baculovirus/Insect Cell System
- Human Erythrocyte Bisphosphoglycerate Mutase: Inactivation by Glycation In Vivo and In Vitro
- Gliclazide Inhibits Proliferation but Stimulates Differentiation of White and Brown Adipocytes
- 1B-03 Effect of exercise training on tumor necrosis factor-α-induced expressions of lipogenic genes in rat adipocytes(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- The experimental system to analyze mRNA expression profiles between slow and fast muscle fibers
- Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells
- Functional roles of N-glycans in cell signaling and cell adhesion in cancer
- Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport
- Kinetic Basis for the Donor Nucleotide-Sugar Specificity of β1,4-N-Acetylglucosaminyltransferase III^1
- Induction of Apoptotic Cell Death in Human Endothelial Cells Treated with Snake Venom: Implication of Intracellular Reactive Oxygen Species and Protective Effects of Glutathione and Superoxide Dismutases
- Disposition of protein-bound 3-nitrotyrosine in rat plasma analysed by a novel protocol for HPLC-ECD
- Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2 : a new mechanism for the emphysema-like changes observed in Fut8-deficient mice
- The Photoreceptor Molecules in Xenopus Tadpole Tail Fin, in which Melanophores Exist(Cell Biology)
- Osmotic Stress Induces HB-EGF Gene Expression via Ca^/Pyk2/JNK Signal Cascades in Rat Aortic Smooth Muscle Cells
- A Defect in the Mitochondrial Import of Mutant Mn-Superoxide Dismutase Produced in Sf21 Cells
- Induction of Aldose Reductase Gene Expression in LEC Rats during the Development of the Hereditary Hepatitis and Hepatoma
- Interference of a methotrexate derivative with urinary oncopterin [N^2-(3-aminopropyl)biopterin] measurement by high-performance liquid chromatography with fluorimetric detection
- Loss of Core Fucosylation of Low-Density Lipoprotein Receptor-Related Protein-1 Impairs Its Function, Leading to the Upregulation of Serum Levels of Insulin-Like Growth Factor-Binding Protein 3 in Fut8^ Mice
- Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis: their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer
- Ligand-Induced Aggregation of the Extracellular Domain of a Heat-Stable Enterotoxin Receptor (Guanylyl Cyclase C)
- Prevention of PERV Infections in Pig to Human Xenotransplantation by the RNA Interference Silences Gene
- The Possiblity of Reducing Xenoantigen Levels with a Novel Gal 3'-Sulfotransferase(GP3ST)
- Regulation of Natural Killer Cell-Mediated Swine Endothelial Cell Lysis through Genetic Remodeling of a Glycontigen
- -0529-CLINICAL SIGNIFICANCE OF MANGANESE-SUPEROXIDE DISMUTASE IN ACUTE MYOCARDIAL INFARCTION
- Nitric Oxide in the Rat Spinal Cord in Freund's Adjuvant-Induced Hyperalgesia
- A Fluorescent Assay Method for GDP-L-Fuc: N-Acetyl-β-D-Glucosaminide α1-6Fucosyltransferase Activity, Involving High Performance Liquid Chromatography
- Phylogeography of the Japanese Giant Flying Squirrel, Petaurista leucogenys, Based on Mitochondrial DNA Control Region Sequences(Animal Diversity and Evolution)
- Roles of N-Terminal Active Cysteines and C-Terminal Cysteine-Selenocysteine in the Catalytic Mechanism of Mammalian Thioredoxin Reductase^1
- Effect of a Nitric Oxide Synthase Inhibitor, S-Ethylisothiourea, on Cultured Cells and Cardiovascular Functions of Normal and Lipopolysaccharide-Treated Rabbits^1
- Age-associated changes in the dopamine synthesis as determined by GTP cyclohydrolase I inhibitor in the brain of senescence-accelerated mouse-prone inbred strains (SAMP8)
- Oxidative Damage Due to Copper Ion and Hydrogen Peroxide Induces GlcNAc-Specific Cleavage of an Asn-Linked Oligosaccharide
- Overexpression of Aldehyde Reductase Protects PC12 Cells from the Cytotoxicity of Methylglyoxal or 3-Deoxyglucosone^1
- Effects of Substitutions of the Conserved Histidine Residues in Humanγ-Glutamyl Transpeptidase
- Fragmentation of Ceruloplasmin Following Non-Enzymatic Glycation Reaction
- The Internalization and Metabolism of 3-Deoxyglucosone in Human Umbilical Vein Endothelial Cells
- Production of a Recombinant Single-Chain Variable-Fragment (scFv) Antibody against Sulfoglycolipid
- 2B1:Postgenome
- Chemical features of monoaminergic and non-monoaminergic neurons in the brain of laboratory shrew(Suncus murinus) are changed by systemic administration of monoamine precursors
- Color changes and behavior in siamese fighting fish (Betta splendens) (1) Cellular receptors concerned in melanophore movements
- Peroxiredoxin IV Is a Secretable Protein with Heparin-Binding Properties under Reduced Conditions^1
- Effects of nerve growth factor and nicotine on the expression of nicotinic acetylcholine receptor subunits in PC12 cells
- Antioxidative Effects of a New Lychee Fruit-Derived Polyphenol Mixture, Oligonol, Converted into a Low-Molecular Form in Adipocytes
- Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate, α2,6-sialylated blood group type 2H (ST2H) antigen
- A STUDY ON THE TOXICITY OF NATURAL FOOD DYES : TOXICITY AND ENZYME INHIBITION IN PARAMECIUM CAUDATUM
- A SCREENING METHOD FOR THE TOXICITY OF FOOD DYES USING ARTEMIA SALINA LARVAE
- Membrane-anchored growth factors, the epidermal growth factor family : Beyond receptor ligands
- CD9 Antigen Interacts with Heparin-Binding EGF-Like Growth Factor through Its Heparin-Binding Domain
- Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease
- 日本糖鎖科学コンソーシアム
- β1, 4-GlcNAc転移酵素IIIの酵素学的性質と生物学的機能
- Different consequences of reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4
- Ectodomain shedding and remnant peptide signalling of EGFRs and their ligands
- Spatiotemporally-regulated interaction between β1 integrin and ErbB4 that is involved in fibronectin-dependent cell migration
- Isoquinoline neurotoxins in the brain and Parkinson's disease
- A Novel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4.
- Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts
- A Fluorescent Assay Method for GDP-L-Fuc:N-Acetyl-.BETA.- D-Glucosaminide .ALPHA.1-6Fucosyltransferase Activity, Involving High Performance Liquid Chromatography.
- Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice
- NTAK.ALPHA. and .BETA. Isoforms Stimulate Breast Tumor Cell Growth by Means of Different Receptor Combinations.
- Induction of Apoptotic Cell Death in Human Endothelial Cells Treated with Snake Venom: Implication of Intracellular Reactive Oxygen Species and Protective Effects of Glutathione and Superoxide Dismutases.