NTAK.ALPHA. and .BETA. Isoforms Stimulate Breast Tumor Cell Growth by Means of Different Receptor Combinations.

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概要

• 論文の詳細を見る

• Neural-and thymus-derived activator for ErbB kinases (NTAK) is a recently described member of the neuregulin family that binds directly to ErbB3 and ErbB4 and transactivates ErbB2. Rat NTAK has at least five alternative-spliced isoforms: α1, α2a, α2b, β, and γ. In order to understand their biological properties, this study focused on the NTAKα2a and β isoforms, which have different EGF-like domains. The effect of these isoforms on cell growth and tyrosine phosphorylation in human breast cancer cells, MBA-ME-453 and T47D, was examined using the recombinant proteins. In terms of cell growth, NTAKα2a and NTAKβ preferentially stimulate T47D cells and MDA-MB-453 cells, respectively, in a dose-dependent manner. Although both NTAKs induce the highest level of tyrosine phosphorylation of ErbB2, NTAKo2a and NTAKβ preferentially induce ErbB3 and ErbB4 phosphorylation, respectively. Thus, NTAKα2a and NTAKβ stimulate cell growth in different ways, by means of different combinations of receptors.

• 社団法人 日本生化学会の論文

著者

• Yamada Kouji

  Institute For Comprehensive Medical Science Fujita Health University

• Ishiguro Hiroshi

  Institute For Comprehensive Medical Science Fujita Health University

• Nakano Norihiko

  Department Of Biochemistry Room B-1 Osaka University Medical School

• Nagatsu Toshiharu

  Institute For Comprehensive Medical Science Fujita Health University

• Kajihara Kenichi

  Department Of Biochemistry Room B-1 Osaka University Medical School

• Higashiyama Shigeki

  Department Of Basic Laboratory Sciences School Of Allied Health Science Osaka University Faculty Of

• Taniguchi Naoyuki

  Department Of Biochemistry Osaka University Graduate School Of Medicine

• Endo Takeshi

  Department Of Biology Faculty Of Science Chiba University

• Kajihara Kenichi

  Department of Biochemistry, Osaka University Medical School

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