Factors Influencing Warfarin Requirements : Warfarin Increases Lactate Dehydrogenase Concentration in Patients with Valve Prostheses
スポンサーリンク
概要
- 論文の詳細を見る
We carried out a retrospective medical chart survey to clarify the effects of various patient factors on warfarin dose requirements. Age, body weight, biochemical data and daily warfarin dose were recorded for 332 outpatients stabilized on warfarin. We found that there was a negative correlation between age and therapeutic warfarin dose (r=-0.3089, p<0.01, n=332), and positive correlations between body weight and therapeutic warfarin dose (r=0.1623, p<0.05, n=213) and lactate dehydrogenase (LDH) concentration and therapeutic warfarin dose (r=0.2071, p<0.01, n=328). The mean serum LDH levels in patients with and without valve prostheses were 561.82±151.06 and 393.61±113.66 IU/L, respectively (p<0.01), suggesting the release of LDH due to red cell hemolysis in patients with valve prostheses. Moreover, the correlation coefficient between LDH concentration and therapeutic warfarin dose in patients with valve prostheses was higher than that in patients without valve prostheses, such greater correlation between LDH concentration and warfarin dose also indicating warfarin-induced release of LDH from red blood cells in patients with valve prostheses.
- 日本医療薬学会の論文
- 2004-09-10
著者
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KOBAYASHI Atsushi
Department of Chemistry, Kyushu University
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Ichikawa Shuichi
Internal Medicine, Kitakanto Cardiovascular Hospital
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Ichikawa Shuichi
Department Of Vascular Medicine Cardiovascular Hospital Of Central Japan (kitakanto Cardiovascular H
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HORIUCHI RYUYA
Department of Clinical Pharmacology, Gunma University Graduate School of Medicine
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Horiuchi Ryuya
Department Of Pharmacy Gunma University Hospital
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TAKAHASHI Kyoko
Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s U
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Sakaguchi Kazuo
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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Sakaguchi Kazuo
Department Of Pharmacy Cardiovascular Hospital Of Central Japan
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Iizuka Keiko
Department of Pharmacy, Gunma University Hospital
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Satoh Haruzo
Department of Pharmacy, Isesaki Municipal Hospital
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Ichikawa Shuichi
Internal Medicine Cardiovascular Hospital Of Central Japan
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Kobayashi Atsushi
Department Of Applied Chemistry The University Of Tokyo
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Iizuka Keiko
Department Of Pharmacy Gunma University Hospital
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Satoh Haruzo
Department Of Pharmacy Isesaki Municipal Hospital
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Takahashi Kyoko
Department Of Food Science And Nutrition School Of Human Environmental Sciences Mukogawa Women'
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Horiuchi Ryuya
Department Of Clinical Pharmacology And Department Of Pharmacy Gunma University School Of Medicine
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Kikuchi A
Department Of Pharmacy Maebashi Red Cross Hospital
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Kobayashi Atsushi
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
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Takahashi Kyoko
Department Of Chemical And Biological Sciences Faculty Of Science Japan Women's University
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Takahashi Kyoko
Department Of Pharmacy Public Tomioka General Hospital
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Takahashi Kyoko
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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