EFFECT OF HEPARIN INJECTION ON PLASMA PROTEIN BINDING OF 1-ANILINO-8-NAPHTHALENESULFONATE AND SALICYLATE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
After intravenous injection of heparin, the plasma protein binding of 1-anilino-8-naphthalenesulfonate (ANS) was remarkably decreased in rats. This effect ocurred within one min after the injection of 1000 units/kg of heparin and lasted for about 30 min. The change in the binding of ANS was closely related to the plasma concentration of free acids (FFA), which was suggested as one of the heparin-induced inhibitors. The free fatty fraction of salicylate in plasma after the intravenous injection of heparin, had a pronounced variation, and also had a statistically significant correlation with the plasma free fraction of ANS. It was suggested that ANS might be useful for the prediction of the heparin-induced changes in the plasma protein binding of acidic drugs.
- 公益社団法人日本薬学会の論文
著者
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Sawada Yasufumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Uni
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Iga Tatsuji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Sato Jun
Faculty of Life Science and Technology, Fukuyama University
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Sugiyama Y
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Sato Jun
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Sato Jun
Faculty Of Engineering Toyo University
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Iga Tatsuji
Division Of Gastroenterology Department Of Medicine Kurume University School Of Medicine
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