Relationship between Pharmacokinetics and the Analgesic Effect of Indomethacin in the Rat
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between the pharmacokinetic properties and the analgesic effect of indomethacin (IDM) was evaluated on a carrageenin-induced inflammation model in the rat. Rats were administered the drug in one of two ways : intravenous (i.v.) IDM bolus or i.v. IDM infusion. The analgesic activity was measured by Randall-Selitto test. No correlation was observed between the analgesic effect and the plasma IDM concentration after i.v. bolus administration of IDM. However, in the case of infusion, IDM produced a dose-dependent analgesic effect. In this paper, we demonstrated that the plasma concentration of IDM maintained by i.v. infusion had a prolonged analgesic effect on the carrageenin-induced inflammation model.
- 公益社団法人日本薬学会の論文
- 1997-04-15
著者
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Shimizu Ryosuke
Faculty Of Pharmaceutical Sciences Nagoya City University
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Suzuki T
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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Aoki Masatada
Biopharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Tokyo
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SUZUKI Toyofumi
Department of Pharmaceutics, College of Pharmacy, Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano M
Department Of Pharmaceutical Science College Of Pharmacy Nihon University
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Shimizu R
(pressent Address)biomedical Research Institue Hab Discussion Group
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Hanano M
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano Manabu
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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SUGANUMA Taiyo
Department of Medical Eudcation, Tokyo Women's Medical University School of Medicine
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Suganuma Taiyo
(pressent Address)department Of Pharmacology Tokyo Women's Medical University
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Suganuma Taiyo
Department Of Medical Eudcation Tokyo Women's Medical University School Of Medicine
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SHIMIZU Ryo
Department of Pharmaceutical Science, College of Pharmacy, Nihon University
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Suzuki Takashi
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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Shimizu Ryo
Department Of Ecosocial System Engineering University Of Yamanashi
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Suganuma Taiyo
Department Of Medical Education Tokyo Women's Medical University
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