Survivin as a Prognostic Factor for Osteosarcoma Patients

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概要

• 論文の詳細を見る

• Purpose: Survivin is one of the apoptosis inhibitor genes and is rarely expressed in adult tissues. However, survivin expression has been detected in various human cancers and correlations have been recognized between the level of expression of this gene in tumors and prognosis. In this study, we investigated the correlations between survivin mRNA expression in osteosarcoma tissues and clinicopathological parameters. Methods: There were 22 osteosarcoma patients in our hospital with paraffin-embedded tissues which could be extracted from biopsy specimens. We used the RT-PCR method after extracting total RNA and conducted a densitometric analysis to determine the ratio of survivin relative to h-GAPDH as an internal marker. Results: Expression of survivin mRNA was detected in all osteosarcoma samples. Patients with metastasis had high survivin mRNA levels in initial biopsy specimens (p<0.01). Moreover, there was a statistically significant difference in survivin mRNA expression between patients with and without metastasis (p<0.01). Conclusion: We concluded that high levels of survivin mRNA expression suggest poor prognosis for osteosarcoma patients.

• 日本組織細胞化学会の論文

著者

• Nemoto Norimichi

  Department of Pathology, Nihon University School of Medicine

• Tabata Keiichi

  日本大学 薬学部臨床医学ユニット

• SUGITANI MASAHIKO

  Department of Pathology, Nihon University School of Medicine

• Tabata Keiichi

  College of Pharmacy, Nihon University

• Suzuki Takashi

  College of Pharmacy, Nihon University

• Sugitani Masahiko

  日本大学 医学部心臓血管外科学分野

• Sano M

  Department Of Pathology School Of Medicine Nihon University

• Sano Makoto

  日本大学 医学部病理学

• Osaka Eiji

  Department of Orthopaedic Surgery, Nihon University School of Medicine

• Osaka Shunzo

  Department of Orthopaedic Surgery, Nihon University School of Medicine

• Yoshida Yukihiro

  Department of Orthopaedic Surgery, Nihon University School of Medicine

• Sugita Hideyuki

  Department of Orthopaedic Surgery, Nihon University School of Medicine

• Asami Satoru

  College of Pharmacy, Nihon University

• Hemmi Akihiro

  Department of Pathology, Nihon University School of Medicine

• Ryu Junnosuke

  Department of Orthopaedic Surgery, Nihon University School of Medicine

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Nemoto Norimichi

  Division Of Pathology Department Of Pathology And Microbiology Nihon University School Of Medicine

• Nemoto Norimichi

  Department Of Iind Pathology Nihon University School Of Medicine

• Sugitani Masahiko

  Department Of Pathology Nihon University School Of Medicine

• Yoshida Y

  Department Of Orthopedic Surgery Nihon University

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Sano Makoto

  Department Of Pathology Keio University School Of Medicine

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• Hinotsu Shiro

  Japanese Wilms Tumor Study (JWiTS) Group

• ASAMI Satoru

  Research Unit of Clinical Medicine, College of Pharmacy, Nihon University

• Yoshida Yukihiro

  Department Of Information Systems Engineering Osaka University

• Osaka Eiji

  Department Of Orthopaedic Surgery Nihon University School Of Medicine

• Asami Satoru

  Research Unit Of Clinical Medicine College Of Pharmacy Nihon University

• Osaka S

  Department Of Orthopedic Surgery Nihon University Nerima Hikarigaoka Hospital

• Osaka Shunzo

  Department Of Orhtopaedic Surgery Nihon University School Of Medicine

• Hemmi Akihiro

  Department Of Pathology Nihon University Nerima Hikarigaoka Hospital

• Hemmi Akihiro

  Department Of Pathology Yamanashi Medical University

• Ryu Junnosuke

  Department Of Orthopedic Surgery Nihon University School Of Medicine

• Ryu Junnosuke

  Department Of Orthopaedic Surgery

• Ootsuka Susumu

  Research Unit Of Clinical Medicine College Of Pharmacy Nihon University:department Of Hospital Pharm

• Suganuma Taiyo

  (pressent Address)department Of Pharmacology Tokyo Women's Medical University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Nemoto Norimichi

  Nihon Univ. School Of Medicine Tokyo Jpn

• Shichino Hiroyuki

  Department Of Pediatrics Division Of Cell Regeneration And Transplantation Advanced Medical Research

• Yoshida Y

  Department Of Orthopedic Surgery Nihon University School Of Medicine

• Yoshida Yukihiro

  Department Of Agricultural Chemistry Faculty Of Agriculture Ibaraki University

• Tabata Keiichi

  School Of Pharmacy Nihon University

• Takase S

  College Of Science And Technology (funabashi Campus) Nihon University

• Hinotsu Shiro

  Department Of Pharmacoepidemiology Kyoto University Graduate School Of Medicine And Public Health

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