Dehydrotrametenonic Acid and Dehydroeburiconic Acid from Poria cocos and Their Inhibitory Effects on Eukaryotic DNA Polymerase α and β

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概要

• 論文の詳細を見る

• A new lanostane-type triterpene acid, (20ξ)-3-oxolanosta-7,9(11),24-trien-21-oic acid (1; dehydrotrametenonic acid), along with a known triterpene acid, dehydroeburiconic acid (2), were isolated from the epidermis of the sclerotia of Poria cocos. The structure of 1 was analyzed on the basis of spectroscopic methods. Compounds 1 and 2 inhibited calf DNA polymerase α and rat DNA polymerase β, with the 50% inhibition values of 45.5 μM (1) and 40.8 μM (2), and 86.5 μM (1) and 30.0 μM (2), respectively.

• 社団法人 日本農芸化学会の論文
• 2004-02-23

著者

• Suzuki Takashi

  College of Pharmacy, Nihon University

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• Kondo Shizuki

  Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd.

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kimura Yumiko

  College Of Pharmacy Nihon University

• Mizushina Yoshiyuki

  Department of Nutritional Science, Kobe-Gakuin University

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• KONDO Seizo

  Central Research Laboratory, Kotaro Pharmaceutical Co., LTD.

• Kokubo Sadayuki

  Food Research And Development Laboratory Morinaga Milk Industry Co. Ltd.

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Tai Takaaki

  Morishita Jintan Co. Ltd.

• Kondo Seizo

  Central Research Laboratory Kotaro Pharmaceutical Co. Ltd.

• Tamura T

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University

• Ukiya Motohiko

  College Of Science And Technology Nihon University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• OSHIKUBO Manabu

  College of Science and Technology, Nihon University

• Oshikubo Manabu

  College Of Science And Technology Nihon University

• Mizushima Y

  Laboratory Of Food And Nutritional Sciences Department Of Nutritional Science Kobe-gakuin University

• Mizushina Y

  Kobe‐gakuin Univ. Kobe Jpn

• Kondo Seizo

  Food Science And Technology Institute Morinaga Milk Industry Co. Ltd.

• Mizushina Yoshiyuki

  Department Of Nutritional Science Kobe Gakuin University

• Takase S

  College Of Science And Technology (funabashi Campus) Nihon University

• Mizushina Yoshiyuki

  Department of Applied Biological Science, Science University of Tokyo

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