Five D : C-Friedo-Oleanane Triterpenes from the Seeds of Trichosanthes kirilowii MAXIM. and Their Anti-inflammatory Effects
スポンサーリンク
概要
- 論文の詳細を見る
Five triterpenes with a D : C-friedo-oleanane skeleton, D : C-friedo-oleana-7,9(11)-diene-3β, 29-diol (3-epikarounidiol), 7-oxo-D : C-friedo-olean-8-en-3β-ol (7-oxoisomultiflorenol), 7-oxo-8β-D : C-friedo-olean-9(11)-ene-3α, 29-diol, D : C-friedo-olean-8-ene-3α, 29-diol (3-epibryonolol), and D : C-friedo-olean-8-ene-3β, 29-diol (bryonolol), the first four of which are new naturally occurring compounds, were isolated from the seeds of Trichosanthes kirilowii MAXIM. The structures were determined by spectral and chemical methods. 3-Epikarounidiol, 7-oxoisomultiflorenol, and 3-epibryonolol showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation in mice. The 50% inhibitory dose of these triterpenes for TPA-induced inflammation (1 μg) was 0.2-0.6 mg/ear.
- 社団法人日本薬学会の論文
- 1994-05-15
著者
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木村 由美子
日本大学薬学部
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安川 憲
日本大学薬学部生薬学研究室
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木村 由美子
College of Pharmacy, Nihon University
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安川 憲
College of Pharmacy, Nihon University
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滝戸 道夫
College of Pharmacy, Nihon University
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秋久 俊博
College of Science and Technology, Nihon University
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田村 利武
College of Science and Technology, Nihon University
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KOKKE Wilhelmus
Zynaxis Cell Science, Inc.,
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Kimura Y
Coll. Of Pharmacy Nihon Univ.
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木村 由美子
College Of Pharmacy Nihon University
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滝戸 道夫
College Of Pharmacy Nihon University
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滝戸 道夫
日本大学薬学部生薬学研究室
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田村 利武
日本大学理工学部物質応用化学科
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田村 利武
College Of Science And Technology Nihon University
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秋久 俊博
日本大学理工学部物質応用化学科
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Yasukawa Ken
Coll. Of Pharmacy Nihon Univ.
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Akihisa T
College Of Pharmacy Nihon University
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秋久 俊博
日本大学理工学部
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Kokke W
Zynaxis Inc.
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木村 由美子
日本大学薬学部分析化学
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